{"id":49881,"date":"2019-05-06T00:00:00","date_gmt":"2019-05-05T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/researchers-at-irb-barcelona-identify-a-protein-that-protects-against-non-alcoholic-fatty-liver-disease\/"},"modified":"2020-11-18T15:06:40","modified_gmt":"2020-11-18T14:06:40","slug":"researchers-at-irb-barcelona-identify-a-protein-that-protects-against-non-alcoholic-fatty-liver-disease","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/researchers-at-irb-barcelona-identify-a-protein-that-protects-against-non-alcoholic-fatty-liver-disease\/","title":{"rendered":"Researchers at IRB Barcelona identify a protein that protects against non-alcoholic fatty liver disease"},"content":{"rendered":"

Non-alcoholic fatty liver disease describes several liver dysfunctions of varying severity, characterised by the accumulation of fat in hepatic cells and not caused by high alcohol consumption.\u00a0One of the most serious forms of fatty acid is non-alcoholic steatohepatitis (NASH), in which the accumulation of fat is accompanied by inflammation.<\/p>\n

In this study, published in the journal\u00a0Cell and\u00a0led by Dr\u00a0\u00a0Antonio Zorzano at IRB Barcelona,\u00a0the researchers have observed a decrease in the levels of Mitofusin 2 in patients with NASH, even in early stages of the disease.<\/p>\n

\u201cMitofusin 2 emerges as a possible therapeutic target to tackle fatty liver, a disease for which no treatments are available. Early diagnosis of this disease is difficult and physicians are currently only recommending weight loss to alleviate the condition,\u201d explains\u00a0Antonio Zorzano,\u00a0senior professor at the University of Barcelona and researcher of the CIBERDEM Programme.<\/p>\n

\u201cWe are now studying different approaches that will allow us to enhance the levels of Mitofusin 2, without producing side effects, and that could be relevant in the treatment of non-alcoholic fatty liver disease,\u201d says\u00a0Mar\u00eda Isabel Hern\u00e1ndez-Alvarez, postdoctoral fellow at IRB Barcelona and first author of the study.<\/p>\n

\u25ba Reference article:\u00a0<\/strong>\u00a0Hern\u00e1ndez-Alvarez MI, Sebasti\u00e1n D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, Plana N, Veiga SR, Hern\u00e1ndez V, Vasconcelos N, Peddinti G, Adrover A, Jov\u00e9 M, Pamplona R, Gordaliza-Alaguero I, Calvo E, Cabr\u00e9 N, Castro R, Boutant M, Sala D, Hyotylainen T, Ore\u0161i\u010d M, Fort J, Errasti-Murugarren E, Rodr\u00edgues CMP, Orozco M, Joven J, Cant\u00f3 C, Palacin M, Fern\u00e1ndez-Veledo S, Vendrell J, Zorzano A. “Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease<\/a>“,\u00a0Cell\u00a0(2019).\u00a0DOI: 10.1016\/j.cell.2019.04.010<\/p>\n

\u25ba More information:<\/strong> IRB Barcelona website [+]<\/a><\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

The protein Mitofusin 2 can act as a protector regarding non-alcoholic fatty liver disease \u2013a pathology affecting about 25 % of the world population-, according to a new study published in\u00a0Cell\u00a0and led by the researcher Antonio Zorzano\u00a0at the Institute for Research in Biomedicine (IRB Barcelona<\/a>) in the Barcelona Science Park.<\/p>\n

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