{"id":49858,"date":"2018-01-22T00:00:00","date_gmt":"2018-01-21T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/researchers-identify-a-protein-that-keeps-metastatic-breast-cancer-cells-dormant\/"},"modified":"2020-11-18T15:05:21","modified_gmt":"2020-11-18T14:05:21","slug":"researchers-identify-a-protein-that-keeps-metastatic-breast-cancer-cells-dormant","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/researchers-identify-a-protein-that-keeps-metastatic-breast-cancer-cells-dormant\/","title":{"rendered":"Researchers identify a protein that keeps metastatic breast cancer cells dormant"},"content":{"rendered":"<p>The time needed for breast cancer metastases (secondary lesions caused by cells that have escaped from the original tumour) to develop varies between patients, and little is known about the mechanisms that govern latency (the dormant state of cells that have already spread through the body)<\/p>\n<p>The team has studied the most common kind of breast tumour\u2014estrogen-positive (ER +) and accounting for 80% of breast cancer tumour cases\u2014that is characterised by a long period of latency with no symptoms. The study has been published today in\u00a0Nature Cell Biology\u00a0(<a href=\"https:\/\/www.nature.com\/articles\/s41556-017-0021-z\" target=\"_blank\" rel=\"noopener noreferrer\">doi:10.1038\/s41556-017-0021-z<\/a>).<\/p>\n<p>The team has identified the protein kinase MSK1 as a key regulator of dormant or latent metastases. Using clinical samples from patients, the scientists have confirmed that ER + breast cancer tumours that do not express MSK1 are associated with a risk of earlier relapse, while those that express this molecule will form metastases later.<\/p>\n<p>\u201cWe are interested in understanding the mechanisms underlying metastasis and the time component of this process. Until now, little was known in preclinical models about the mechanisms that allow breast cancer cells to leave the latent state and even less is known in patients,&#8221; explains\u00a0Roger Gomis, head of the\u00a0<a href=\"https:\/\/www.irbbarcelona.org\/ca\/research\/growth-control-and-cancer-metastasis\" target=\"_blank\" rel=\"noopener noreferrer\">Growth Control and Cancer Metastasis Lab<\/a>.<\/p>\n<p>The researchers believe that in the future this discovery may benefit patients in two ways. Firstly, it will help to identify those with an imminent risk of relapse and to adjust the treatment for this prognosis. Secondly, attempts could be made to design a treatment to mimic the function of MSK1 kinase, with the aim to maintain metastatic lesions in a latent and asymptomatic state for as long as possible.<br \/>\n\u00a0<\/p>\n<p>\u25ba More information:\u00a0<a href=\"https:\/\/www.irbbarcelona.org\/en\/news\/researchers-identify-a-protein-that-keeps-metastatic-breast-cancer-cells-dormant\" target=\"_blank\" rel=\"noopener noreferrer\">IRB Barcelona website [+]<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study headed by ICREA researcher\u00a0Roger Gomis\u00a0at the Institute for Research in Biomedicine (<a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_000001&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fes%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_keywords%3Dirb%26_cercador_WAR_empleatsempresesportlet_tab%3D1\" target=\"_blank\" rel=\"noopener noreferrer\">IRB Barcelona<\/a>) at PCB has\u00a0identified the genes involved in the latent asymptomatic state of breast cancer metastases. The work sheds light on the molecular basis underlying how the expression of certain genes facilitates the spread of metastatic lesions.<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":54469,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49858","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Researchers identify a protein that keeps metastatic breast cancer cells dormant - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/researchers-identify-a-protein-that-keeps-metastatic-breast-cancer-cells-dormant\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Researchers identify a protein that keeps metastatic breast cancer cells dormant - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"A study headed by ICREA researcher\u00a0Roger Gomis\u00a0at the Institute for Research in Biomedicine (IRB Barcelona) at PCB has\u00a0identified the genes involved in the latent asymptomatic state of breast cancer metastases. 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