{"id":49857,"date":"2016-10-04T00:00:00","date_gmt":"2016-10-03T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/researchers-identify-a-key-molecule-in-psoriasis-development\/"},"modified":"2020-11-18T15:05:19","modified_gmt":"2020-11-18T14:05:19","slug":"researchers-identify-a-key-molecule-in-psoriasis-development","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/researchers-identify-a-key-molecule-in-psoriasis-development\/","title":{"rendered":"Researchers identify a key molecule in psoriasis development"},"content":{"rendered":"<p>The study shows that skin with psoriasis has a high increase of the\u00a0TREX2\u00a0expression that focuses on the cell nucleus of keratinocyte \u2013the most abundant cells on the skin- which are spreading, dying and differentiating in a strange way. Therefore, the results suggest an important role of the processing DNA gene.<\/p>\n<p>\u201cIn our study, we highlight the essential role of\u00a0TREX2\u00a0promoting DNA degradation and its consequent cell death of keratinocyte, influencing the skin immune response. The release of several signals by skin cells that are dying contributes to the creation and spreading of the chronic immune response and hyper-proliferation and irregular differentiation of epidermis\u201d, says Joan Manils, first author of the study and member of the mentioned department and post-doctorate researcher at the Trinity Biomedical Sciences Institute (Ireland).<\/p>\n<p>The results show\u00a0TREX2\u00a0as a potential therapeutic target to tackle this disease with a different and more focused strategy. \u201cMost of the current treatments are aimed at blocking the action of the immune system and if they have good results, these treatments are chronic and involve the immune response of the sick person\u201d, says Francisco Ciruela, co-author of the study, Professor at the Department of Pathology and Experimental Therapeutics of the UB and Head of the Research Group on Neuropharmacology and Pain at IDIBELL.<\/p>\n<p>The next objective of the researchers is to decode the action mechanism of\u00a0TREX2\u00a0in the development and maintenance of psoriasis, so as to design new therapeutic strategies for the treatment of this disease.<\/p>\n<p>\n\u2022<strong> More information on<a href=\"http:\/\/www.ub.edu\/web\/ub\/en\/menu_eines\/noticies\/2016\/10\/003.html?\"> UB webiste [+]<\/a><\/strong><\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study published in<a href=\"http:\/\/www.jidonline.org\/article\/S0022-202X(16)31961-3\/pdf\" target=\"_self\" rel=\"noopener noreferrer\">\u00a0<\/a>Journal of Investigative Dermatology\u00a0has identified a potential therapeutic target for the treatment of psoriasis. The work shows that the TREX2 gene has a relevant role in the inflammatory response that develops during the illness. The research \u2013led by researchers from the Department of Pathology and Experimental Therapeutics of the<a href=\"http:\/\/www.ub.edu\/medicina\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u00a0Faculty of Medicine and Health Sciences<\/a>\u00a0of the University of Barcelona and the\u00a0Bellvitge Biomedical Research Institute (<a href=\"http:\/\/www.idibell.cat\/ca\" target=\"_blank\" rel=\"noopener noreferrer\">IDIBELL<\/a>)\u2013\u00a0\u00a0counts with the participation of experts from the Scientific and Technologic Centers of the UB\u00a0(<a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_000152&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_tab%3D1%26_cercador_WAR_empleatsempresesportlet_keywords%3Dcentres\" target=\"_blank\" rel=\"noopener noreferrer\">CCiTUB<\/a>)\u00a0based at the Barcelona Science Park (PCB).<\/p>\n","protected":false},"author":1,"featured_media":54465,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49857","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Researchers identify a key molecule in psoriasis development - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/researchers-identify-a-key-molecule-in-psoriasis-development\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Researchers identify a key molecule in psoriasis development - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"A study published in\u00a0Journal of Investigative Dermatology\u00a0has identified a potential therapeutic target for the treatment of psoriasis. The work shows that the TREX2 gene has a relevant role in the inflammatory response that develops during the illness. The research \u2013led by researchers from the Department of Pathology and Experimental Therapeutics of the\u00a0Faculty of Medicine and Health Sciences\u00a0of the University of Barcelona and the\u00a0Bellvitge Biomedical Research Institute (IDIBELL)\u2013\u00a0\u00a0counts with the participation of experts from the Scientific and Technologic Centers of the UB\u00a0(CCiTUB)\u00a0based at the Barcelona Science Park (PCB).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pcb.ub.edu\/en\/researchers-identify-a-key-molecule-in-psoriasis-development\/\" \/>\n<meta property=\"og:site_name\" content=\"Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"article:published_time\" content=\"2016-10-03T23:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-18T14:05:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2016\/10\/16057083205fb52a2020674.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"700\" \/>\n\t<meta property=\"og:image:height\" content=\"427\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"adminpcb\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"adminpcb\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/researchers-identify-a-key-molecule-in-psoriasis-development\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/researchers-identify-a-key-molecule-in-psoriasis-development\\\/\"},\"author\":{\"name\":\"adminpcb\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/d13cab05cd0a75b17fddca8496481021\"},\"headline\":\"Researchers identify a key molecule in psoriasis development\",\"datePublished\":\"2016-10-03T23:00:00+00:00\",\"dateModified\":\"2020-11-18T14:05:19+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/researchers-identify-a-key-molecule-in-psoriasis-development\\\/\"},\"wordCount\":262,\"image\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/researchers-identify-a-key-molecule-in-psoriasis-development\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2016\\\/10\\\/16057083205fb52a2020674.jpeg\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/researchers-identify-a-key-molecule-in-psoriasis-development\\\/\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/researchers-identify-a-key-molecule-in-psoriasis-development\\\/\",\"name\":\"Researchers identify a key molecule in psoriasis development - 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The research \u2013led by researchers from the Department of Pathology and Experimental Therapeutics of the\u00a0Faculty of Medicine and Health Sciences\u00a0of the University of Barcelona and the\u00a0Bellvitge Biomedical Research Institute (IDIBELL)\u2013\u00a0\u00a0counts with the participation of experts from the Scientific and Technologic Centers of the UB\u00a0(CCiTUB)\u00a0based at the Barcelona Science Park (PCB).","og_url":"https:\/\/www.pcb.ub.edu\/en\/researchers-identify-a-key-molecule-in-psoriasis-development\/","og_site_name":"Parc Cient\u00edfic de Barcelona","article_published_time":"2016-10-03T23:00:00+00:00","article_modified_time":"2020-11-18T14:05:19+00:00","og_image":[{"width":700,"height":427,"url":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2016\/10\/16057083205fb52a2020674.jpeg","type":"image\/jpeg"}],"author":"adminpcb","twitter_card":"summary_large_image","twitter_misc":{"Written by":"adminpcb","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.pcb.ub.edu\/en\/researchers-identify-a-key-molecule-in-psoriasis-development\/#article","isPartOf":{"@id":"https:\/\/www.pcb.ub.edu\/en\/researchers-identify-a-key-molecule-in-psoriasis-development\/"},"author":{"name":"adminpcb","@id":"https:\/\/www.pcb.ub.edu\/es\/#\/schema\/person\/d13cab05cd0a75b17fddca8496481021"},"headline":"Researchers identify a key molecule in psoriasis development","datePublished":"2016-10-03T23:00:00+00:00","dateModified":"2020-11-18T14:05:19+00:00","mainEntityOfPage":{"@id":"https:\/\/www.pcb.ub.edu\/en\/researchers-identify-a-key-molecule-in-psoriasis-development\/"},"wordCount":262,"image":{"@id":"https:\/\/www.pcb.ub.edu\/en\/researchers-identify-a-key-molecule-in-psoriasis-development\/#primaryimage"},"thumbnailUrl":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2016\/10\/16057083205fb52a2020674.jpeg","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.pcb.ub.edu\/en\/researchers-identify-a-key-molecule-in-psoriasis-development\/","url":"https:\/\/www.pcb.ub.edu\/en\/researchers-identify-a-key-molecule-in-psoriasis-development\/","name":"Researchers identify a key molecule in psoriasis development - 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