{"id":49852,"date":"2020-05-18T00:00:00","date_gmt":"2020-05-17T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/researchers-identify-a-key-factor-in-the-development-of-luminal-breast-cancer\/"},"modified":"2020-11-18T15:05:10","modified_gmt":"2020-11-18T14:05:10","slug":"researchers-identify-a-key-factor-in-the-development-of-luminal-breast-cancer","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/researchers-identify-a-key-factor-in-the-development-of-luminal-breast-cancer\/","title":{"rendered":"Researchers identify a key factor in the development of luminal breast cancer"},"content":{"rendered":"<p>The <a href=\"https:\/\/www.irbbarcelona.org\/en\/research\/translational-control-of-cell-cycle-and-differentiation\" target=\"_blank\" rel=\"noopener noreferrer\">Translational Control of Cell Cycle and Differentiation Lab<\/a> at IRB Barcelona, led by ICREA researcher\u00a0Ra\u00fal M\u00e9ndez, has published a study in the journal Science Advances that has identified a key factor in the development of luminal breast cancer.<\/p>\n<p>Characterised by the expression of estrogen receptors, luminal tumours are the most common subtype of breast cancer. The mammary gland is the only organ in our body to undergo its greatest development after birth, as a result of fluctuations in hormone levels. This makes this gland a good model to study cell differentiation and also the mechanisms that regulate the progression of breast cancer.<\/p>\n<p>\u201cTraditionally, much attention has been devoted to the in-depth study of how hormones regulate the development of the mammary gland at the transcriptional level, that is, the synthesis of messenger RNA from DNA. In previous work by our group, we had discovered that factors called CPEBs regulate the next step, namely the translation of that messenger RNA into protein. This process is crucial for embryo development, and it is deregulated during the development in tumours other than those in the breast, such as those of the pancreas,\u201d explains M\u00e9ndez.<\/p>\n<p>The IRB Barcelona research team has discovered that CPEB2 is essential for protein synthesis after hormonal stimulation, the latter a process that regulates both the proper development of the mammary gland and the formation of luminal breast tumours.<\/p>\n<p>\n<strong>\u25ba Reference article:\u00a0<\/strong>Rosa Pascual, Judit Mart\u00edn, Fernando Salvador, Oscar Reina, Veronica Chanes, Alba Millanes-Romero, Clara Su\u00f1er, Gonzalo Fern\u00e1ndez-Miranda, Anna Bartomeu, Yi-Shuian Huang, Roger R. Gomis and Ra\u00fal M\u00e9ndez. &#8220;<a href=\"https:\/\/advances.sciencemag.org\/content\/6\/20\/eaax3868?rss=1\" target=\"_blank\" rel=\"noopener noreferrer\">The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer<\/a>&#8220;.Science Advances\u00a0(2020) DOI: 10.1126\/sciadv.aax3868<\/p>\n<p><strong>\u25ba For further information: <a href=\"https:\/\/www.irbbarcelona.org\/en\/news\/identification-of-a-determining-factor-in-luminal-cancer-cells-that-cause-the-greatest-number\" target=\"_blank\" rel=\"noopener noreferrer\">IRB Barcelona website [+]<\/a><\/strong><\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at <a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_000001&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_tab%3D1%26_cercador_WAR_empleatsempresesportlet_keywords%3Dirb\" target=\"_blank\" rel=\"noopener noreferrer\">IRB Barcelona<\/a> in the Barcelona Science Park discover a new mechanism in estrogen receptor-positive breast cancer cells. The work reveals that the inhibition of CPEB2, a key factor in the estrogen signalling pathway, causes cancer cells to proliferate less and protects mice against luminal breast cancer.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":54445,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49852","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Researchers identify a key factor in the development of luminal breast cancer - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/researchers-identify-a-key-factor-in-the-development-of-luminal-breast-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Researchers identify a key factor in the development of luminal breast cancer - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Researchers at IRB Barcelona in the Barcelona Science Park discover a new mechanism in estrogen receptor-positive breast cancer cells. 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