{"id":49757,"date":"2019-08-30T00:00:00","date_gmt":"2019-08-29T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/nanovectors-could-improve-the-combined-administration-of-antimalarial-drugs\/"},"modified":"2020-11-18T14:59:11","modified_gmt":"2020-11-18T13:59:11","slug":"nanovectors-could-improve-the-combined-administration-of-antimalarial-drugs","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/nanovectors-could-improve-the-combined-administration-of-antimalarial-drugs\/","title":{"rendered":"Nanovectors could improve the combined administration of antimalarial drugs"},"content":{"rendered":"<p>Combining two drugs that act through different mechanisms is one of the most efficient approaches currently used to treat malaria. However, differences in the drugs\u2019 physichochemical properties (solubility, half-life, etc.) often affect treatment efficacy. To overcome this obstacle, Fern\u00e1ndez Busquets and his team have developed a nanovector \u2013consisting of small spheres or liposomes\u2013 that can simultaneously transport compounds that are soluble in water (hydrophilic) and in lipids (lipophylic). \u201cBy encapsulating both drugs in the same nanovector, we make sure that both will persist for the same time in the organism,\u201d explains Fern\u00e1ndez-Busquets.<\/p>\n<p>As proof of concept, the research team introduced the water-soluble drug pyronaridine in the liposome lumen and the lipid-soluble drug atovaquone in its membrane. In addition, they covered the liposome with an antibody that recognises a protein expressed by red blood cells (whether they are infected or not) and gametocytes (the sexual phase of the parasite, responsable for host-to-host transmission). Hence the term immunoliposome.<\/p>\n<p>The results show that both drugs, when encapsulated, i nhibited parasite growth in vitro at concentrations that had no effect when used as free drugs. Thanks to the antibodies, the liposomes rapidly bound to the target cells and efficiently delivered the drug.\u00a0<\/p>\n<p>The authors argue that this strategy could be used in a near future to treat severe cases of malaria that are admitted in hospitals, where intravenous administration of liposomes is feasible. The challenge lies in developing nanovectors adequate for oral administration in order to treat non-complicated malaria, a line of work the research group is currently exploring.<\/p>\n<p>\u201cCurrent treatments target mostly the asexual phases of the parasite. This new strategy would also target the sexual phase or gametocyte, the only phase that can be transmitted from humans to mosquitoes, and would thereby contribute to reducing the emergence and spread of antimalarial resistance,\u201d adds the researcher.<\/p>\n<p>\n<strong>\u25ba Reference article: <\/strong>Biosca A, Dirscherl L, Moles E, Imperial S, Fern\u00e0ndez-Busquets X. An ImmunoPEGliposome for Targeted Antimalarial Combination Therapy at the Nanoscale. Pharmaceutics. 2019 Jul 16;11(7). pii: E341.<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31315185\" style=\"font-weight: 200\" target=\"_blank\" rel=\"noopener noreferrer\">doi: 10.3390\/pharmaceutics11070341<\/a>.<\/p>\n<p><strong>\u25ba For further information: <\/strong><a href=\"https:\/\/www.ibecbarcelona.eu\/nanovectors-could-improve-the-combined-administration-of-antimalarial-drugs\/\" target=\"_blank\" rel=\"noopener noreferrer\">IBEC website [+]<\/a><\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Encapsulating two drugs with different properties into nanovesicles surrounded by antibodies can greatly improve their delivery and efficacy, according to a study led by Xavier Fern\u00e1ndez Busquets, director of the joint Nanomalaria unit at the Institute for Bionengineering of Catalonia (<a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_000134&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_tab%3D1%26_cercador_WAR_empleatsempresesportlet_keywords%3Dibec\" target=\"_blank\" rel=\"noopener noreferrer\">IBEC<\/a>), in the Barcelona Science Park, and the Barcelona Institute for Global Health (<a href=\"https:\/\/www.isglobal.org\/en\/\" target=\"_blank\" rel=\"noopener noreferrer\">ISGlobal<\/a>), supported by \u201dla Caixa\u201d.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":54117,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49757","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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