{"id":49749,"date":"2016-11-18T00:00:00","date_gmt":"2016-11-17T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/omega-3-fatty-acids-stimulate-brown-adipose-tissue-metabolism\/"},"modified":"2020-11-18T14:59:01","modified_gmt":"2020-11-18T13:59:01","slug":"omega-3-fatty-acids-stimulate-brown-adipose-tissue-metabolism","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/omega-3-fatty-acids-stimulate-brown-adipose-tissue-metabolism\/","title":{"rendered":"Omega-3 fatty acids stimulate brown adipose tissue metabolism"},"content":{"rendered":"

In the new study, carried out in laboratory animal models, the research team noticed that Omega-3 fatty acids (n-3 PUFAS) stimulate the activation of brown and beige adipose tissue through a specific receptor (GPR120), which enables the release of the hormone FGF21 (21 fibroblast growth factor). This hormone, built by the adipocyte, is a molecule that regulates lipid glucose and metabolism and therefore, it is an effective target for the action mechanism of Omega-3.<\/p>\n

\u201cThis discovery has implications in the understanding of the positive effects of n-3 PUFAS on the control of metabolic diseases and other aspects regarding the treatment for obesity and type 2 diabetes\u201d, says Professor Francesc Villarroya, \u00a0and head of the Research Group in Genetics and Molecular Biology of Mitochondrial Proteins and Associated Diseases.<\/p>\n

The study shows that Omega-3 fatty acids enable the adaptive thermogenesis in mammals\u2019 brown adipose tissue, an essential mechanism for the adaption of the organism to cold environments. With rodents, it has been proved that the brown adipose tissue is able to create warmth and protect from obesity through the activation of energy expenditure.<\/p>\n

According to the conclusions of the article published in\u00a0Nature Communications, the specific receptor GPR120 for the Omega poli-unsaturated fatty acids enables the activation of brown adipose tissue, which is linked \u2013in several scientific studies- to protection from obesity and metabolic diseases such as diabetes or dyslipemia (alterations in lipid metabolism).
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\u2022 For further information:\u00a0UB website [+]<\/a><\/strong><\/p>\n

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Omega-3 fatty acids are able to stimulate the activation of brown and beige adipose tissues, a discovery that would promote the development of new therapies for obesity and other metabolism diseases, according to a research study published in the journal\u00a0Nature Communications\u00a0<\/a>under the supervision of Professor Francesc Villarroya, from the\u00a0Department of Biochemistry and Molecular Biomedicine\u00a0<\/a>and member of the Institute of Biomedicine of the University of Barcelona (IBUB)<\/a>\u00a0\u2013located at PCB\u2013\u00a0and the\u00a0<\/a>Biomedical Research Center Red-Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN<\/a>)\u00a0of the Institute of Health Carlos III.<\/p>\n

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