{"id":49643,"date":"2019-07-11T00:00:00","date_gmt":"2019-07-10T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/unravelling-the-three-dimensional-genomic-structure-of-male-germ-cells\/"},"modified":"2020-11-18T14:56:07","modified_gmt":"2020-11-18T13:56:07","slug":"unravelling-the-three-dimensional-genomic-structure-of-male-germ-cells","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/unravelling-the-three-dimensional-genomic-structure-of-male-germ-cells\/","title":{"rendered":"Unravelling the three-dimensional genomic structure of male germ cells"},"content":{"rendered":"<p>The code of life (genome) is not just a linear sequence of letters, but is also folded (compartmentalised) into a specifically tailored chromatin structure within the cell nuclei. This three-dimensional genomic structure is fundamental, given that it determines which genes \u201cturn on\u201d and which are \u201cturned off\u201d in each cell types.<\/p>\n<p>A new study led by scientists from the UAB and the CNAG-CRG and published in\u00a0Cell Reports\u00a0reveals the three-dimensional genomic structure of male germ cells. The study, carried out on mice, shows that this structure is extremely dynamic during the formation of germ cells (gamete precursor cells). Moreover, the study revealed a fine-tuned balance between chromatin remodelling, architectural proteins such as cohesins and gene expression during this process.<\/p>\n<p>All sexually reproducing organisms form haploid gametes (oocytes and sperm) \u2013 each cell type carrying only one copy of each chromosome &#8211; through two consecutive cell divisions preceded by one round of genome replication. This process is known as meiosis and implies that the genome must be packaged and unpackaged in a precise and highly regulated manner.<\/p>\n<p>\u201cOur work shows the dynamics of chromatin remodelling during the formation of male gametes, by comparing changes in chromatin folding and gene transcription at different moments throughout male meiosis&#8221;, says coordinator of the study Aurora Ruiz-Herrera, researcher at the\u00a0<a href=\"https:\/\/www.uab.cat\/web\/departamento-de-biologia-animal-de-biologia-vegetal-y-de-ecologia-1283928459885.html\" target=\"_blank\" rel=\"noopener noreferrer\">Department of Cell Biology, Physiology and Immunology<\/a>\u00a0of the\u00a0<a href=\"https:\/\/ibb.uab.cat\/\" target=\"_blank\" rel=\"noopener noreferrer\">Institute of Biotechnology and Biomedicine (IBB)<\/a>\u00a0at the UAB, where she leads the\u00a0<a href=\"http:\/\/grupsderecerca.uab.cat\/evolgenom\/\" target=\"_blank\" rel=\"noopener noreferrer\">research group in Animal Genomics<\/a>. \u201cWe have thus demonstrated the existence of different degrees of genome folding and how these different levels of genome organization are related to structural proteins such as cohesins and gene expression. The results will pave the way for new investigations into the molecular mechanisms regulating these changes.\u201d<\/p>\n<p>\u201cThis study has been possible only thanks to the combination of complementary techniques in biology such as molecular genetics, microscope imaging and computer simulations. It truly is a multidisciplinary project\u201d, explains Marc A. Marti-Renom,\u00a0<a href=\"https:\/\/www.icrea.cat\/Web\/ScientificStaff\/-215757\" target=\"_blank\" rel=\"noopener noreferrer\">ICREA<\/a>\u00a0researcher and head of the\u00a0<a href=\"http:\/\/sgt.cnag.cat\/www\/home\/\" target=\"_blank\" rel=\"noopener noreferrer\">Structural Genomics Group<\/a>\u00a0at the\u00a0<a href=\"https:\/\/cnag.crg.eu\/\" target=\"_blank\" rel=\"noopener noreferrer\">CNAG-CRG<\/a>\u00a0and co-leader of the study.<\/p>\n<p>The project represents a significant advance in the study of the mechanisms generating and regulating the 3D structure and function of the genome during the formation of gametes. Determining these mechanisms is fundamental, given that the deregulation of this process can lead to diseases such as infertility and chromosome alterations like trisomy 21.<\/p>\n<p><strong>\u25ba More information:<a href=\"https:\/\/www.cnag.crg.eu\/news\/unravelling-three-dimensional-genomic-structure-male-germ-cells\" target=\"_blank\" rel=\"noopener noreferrer\"> Web del CNAG-CRG\u00a0[+]<\/a><\/strong><\/p>\n<p><strong>\u25ba Reference article:\u00a0<\/strong>C. Vara, A. Paytuv\u00ed-Gallart, I. Cuartero et al. &#8220;<a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(19)30803-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124719308034%3Fshowall%3Dtrue\" target=\"_blank\" rel=\"noopener noreferrer\">Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis<\/a>&#8220;.\u00a0Cell Reports\u00a028, 1-16 (2019).\u00a0DOI: 10.1016\/j.celrep.2019.06.037<\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study led by scientists of the National Centre for Genomic Analysis (<a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_006440&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_keywords%3Dcnag%26_cercador_WAR_empleatsempresesportlet_tab%3D1\" target=\"_blank\" rel=\"noopener noreferrer\">CNAG-CRG<\/a>) \u2013based in the Barcelona Science Park and integrated into the Centre for Genomic Regulation (CRG)\u2013\u00a0 and the Universitat Aut\u00f2noma de Barcelona (<a href=\"https:\/\/www.uab.cat\/web\/universitat-autonoma-de-barcelona-1345467954774.html\" target=\"_blank\" rel=\"noopener noreferrer\">UAB<\/a>) reveals the three-dimensional genomic structure of male germ cells and how this structure determines their function. The study, published in the journal\u00a0Cell Reports, represents a significant advance in our understanding of how the dynamics of insulator proteins and transcriptional activity are coupled during the 3D genome re-organisation that takes place during the formation of male germ cells.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":53691,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49643","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Unravelling the three-dimensional genomic structure of male germ cells - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/unravelling-the-three-dimensional-genomic-structure-of-male-germ-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Unravelling the three-dimensional genomic structure of male germ cells - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"A study led by scientists of the National Centre for Genomic Analysis (CNAG-CRG) \u2013based in the Barcelona Science Park and integrated into the Centre for Genomic Regulation (CRG)\u2013\u00a0 and the Universitat Aut\u00f2noma de Barcelona (UAB) reveals the three-dimensional genomic structure of male germ cells and how this structure determines their function. 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