{"id":49640,"date":"2015-06-21T00:00:00","date_gmt":"2015-06-20T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/researchers-develop-a-new-family-of-bioinspired-antibiotic-compounds\/"},"modified":"2020-11-18T14:56:07","modified_gmt":"2020-11-18T13:56:07","slug":"researchers-develop-a-new-family-of-bioinspired-antibiotic-compounds","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/researchers-develop-a-new-family-of-bioinspired-antibiotic-compounds\/","title":{"rendered":"Researchers develop a new family of bioinspired antibiotic compounds"},"content":{"rendered":"<p>Bacterial resistance to almost all available antibiotics is an important public health issue. Moreover, the development of effective antibiotics has slowed down. Only seven new antibiotics were approved by the Food and Drug Administration (FDA) from 2003 to 2012 (only two new classes since 1998). All this makes it clear that there is an urgent need to develop new antibiotics against bacteria that are prone to acquire resistance to the antibiotics currently in use, particularly Gram-negative bacteria. To give an example, more people die in USA of methicillin-resistant\u00a0<em>Staphylococcus aureus<\/em>\u00a0than of AIDS.<\/p>\n<p>\u201cThe main goal of the study has been to design, synthetize and prove in vitro activity and in vivo toxicity of a new series of polymyxin, which present potential advantages over currently existing antibiotics\u201d, explains Francesc Rabanal, member of the European consortium\u00a0<a href=\"http:\/\/www.ub.edu\/web\/ub\/es\/menu_eines\/noticies\/2014\/02\/020.html?\" target=\"_blank\" rel=\"noopener noreferrer\">ENABLE<\/a>. \u201cOne of these advantages is that these antibiotics can act against Gram-negative bacteria, including resistant and multi-resistant strains, which are the most dangerous from the point of view of public health; in addition, they show activity against\u00a0<em>S. aureus<\/em>\u00a0(Gram-positive bacteria)\u201d, concludes the UB researcher.<\/p>\n<div><strong>Bioinspired compounds<\/strong><\/div>\n<p>New compounds designed by Catalan researchers are inspired by cyclic natural antimicrobial peptides (AMPs), particularly polymyxins, a polypeptide antibiotic produced by a<em>\u00a0Bacillus polymyxa\u00a0<\/em>strain which shows some toxicity problems even if it is used as last resort option at hospitals. Design has included a disulphide bond in polymyxin structure which facilitates large-scale synthesis and reduces toxicity.<\/p>\n<div>\u201cThe main objective of the study was to design cyclic lipopeptides with a chemically accessible structure, high activity and low toxicity\u201d, emphasizes Rabanal. \u201cThe next step is to optimise this prototype compound (named\u00a0hit\u00a0in the field of pharmacy) in order to obtain a therapeutic candidate (lead) that could be developed in clinical trials and get the market\u201d, concludes the researcher.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>A group of researchers, led by Francesc Rabanal, professor in the\u00a0<a href=\"http:\/\/www.qo.ub.es\/en\/departament\/benvinguda\" target=\"_blank\" rel=\"noopener noreferrer\">Department of Organic Chemistry<\/a>\u00a0of the University of Barcelona (<a href=\"http:\/\/www.ub.edu\/web\/ub\/en\/index.html?\" target=\"_blank\" rel=\"noopener noreferrer\">UB<\/a>), has published in\u00a0Scientific Reports (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26024044\" target=\"_blank\" rel=\"noopener noreferrer\">d<\/a><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26024044\" target=\"_blank\" rel=\"noopener noreferrer\">oi:10.1038\/srep10558<\/a>)\u00a0\u2013an open access journal from the publishers of Nature\u2013\u00a0the first results of a study of a new antibacterial compound based on natural peptides capable of selectively killing resistant pathogens.\u00a0The institutions who have participated in the project are the Faculty of Chemistry and\u00a0the Faculty of Pharmacy of the UB,\u00a0the Centre of Research in Toxicology (<a href=\"http:\/\/www.catalonia.com\/en\/our-services\/tecnio\/CERETOX.jsp\" target=\"_self\" rel=\"noopener noreferrer\">CERETOX<\/a>) \u2013located at the\u00a0Barcelona Science Park (PCB)\u2013\u00a0as well as the Barcelona Institute for Global Health (<a href=\"http:\/\/www.isglobal.org\/en\/\" target=\"_blank\" rel=\"noopener noreferrer\">CRESIB-ISGlobal<\/a>) and the <a href=\"http:\/\/www.hospitalclinic.org\/en\" target=\"_blank\" rel=\"noopener noreferrer\">Hospital Cl\u00ednic of Barcelona<\/a>.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":53679,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49640","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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