{"id":49634,"date":"2016-05-20T00:00:00","date_gmt":"2016-05-19T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/first-signalling-pathway-of-the-digestive-lineage-in-planarians-is-described\/"},"modified":"2020-11-18T14:56:04","modified_gmt":"2020-11-18T13:56:04","slug":"first-signalling-pathway-of-the-digestive-lineage-in-planarians-is-described","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/first-signalling-pathway-of-the-digestive-lineage-in-planarians-is-described\/","title":{"rendered":"First signalling pathway of the digestive lineage in planarians is described"},"content":{"rendered":"<p>The planarian\u00a0<em>Schmidtea mediterranea<\/em>\u00a0is an invertebrate used as a model in studies for genetics of development and biomedical research. It shows a great regenerative ability, based on pluripotent adult stem cells \u2013neoblasts- which are maintained over all the life cycle of the organism, and is an exceptional model to study the behaviour of these stem cells in vivo in regenerative processes of an animal using a small part of it. In regenerative medicine, research with planarians could promote the design of future therapies based on stem cell transplant or differentiated cells taken from stem cells in patients affected by neurodegenerative illnesses (Parkinson, Alzheimer, etc.), diabetes or cardiac pathologies.<\/p>\n<p>According to Professor Francesc Cebri\u00e0, who directed this scientific project \u2013published in an article of the distinguished magazine\u00a0Development\u00a0(<a href=\"http:\/\/dev.biologists.org\/content\/early\/2016\/04\/28\/dev.131995\" target=\"_blank\" rel=\"noopener noreferrer\">doi:\u00a010.1242\/dev.131995<\/a>)\u2013\u2013, \u201cthe neoblasts, which are the only cells with ability to be divided, are necessary for the renewal of cells that die in the physiologic usual renewal or tissue homeostasis. When we cut a planaria, neoblasts are equally needed to regenerate tissues and amputated organs\u201d.<\/p>\n<p>\u201cWe still do not know how these progenitors end up differentiating from the several cell types\u201d says Cebri\u00e0. \u201cIn most of the cases, we do not know the signalling pathways or genetic programs regulating this final differentiation of the different cell types coming from their progenitors. It is known from long ago that neoblasts are not a homogeneous cell population: some show specific transcription factors which derive to particular lineages. That means they are no longer pluripotent neoblasts but specialized progenitors: for example, progenitors shown by the transcription factors sim or coe, give place to particular neural types, and it has been postulated that progenitors expressing\u00a0hnf4\u00a0or gata4\/5\/6 would give place to digestive cells\u201d.<br \/>\n\u00a0<\/p>\n<p><strong>EGFR pathway: revealing enigmas about cell differentiation<\/strong><\/p>\n<p>Since the discovery of the epidermal growth factors (EGF) in 1962, isolated by Stanley Cohen (Nobel Prize in Medicine 1986), the route of epidermal growth factor receptors (EGFR) has been linked to cell proliferation processes, cancer and designs for new oncology therapies. Previous planaria studies suggest that the EGFR pathway could regulate the differentiation of different cell types (pigment cells in eyes, pharynx, excretory cells or different neural types, etc.). However, there is still no definite evidence and there are lots of unanswered enigmas about the mechanisms of differentiation of different progenitor cells on specific cell types.<\/p>\n<p>This is the first scientific study that shows the fundamental role of the EGFRs pathway in the final differentiation of a particular cell type: in this case, the digestive system cells. In order to have the results, the experts have combined RNA interference experiments to silence the function of genes and markers with ethinil-deoxyuridine (EdU) to know the final destiny of the cells coming from the neoblasts.<br \/>\n\u00a0<\/p>\n<p>\u2022 More information on <a href=\"http:\/\/www.ub.edu\/web\/ub\/en\/menu_eines\/noticies\/2016\/05\/043.html?\" target=\"_blank\" rel=\"noopener noreferrer\">UB website [+]<\/a>\u00a0<\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A scientific study made\u00a0by the researchers Francesc Cebri\u00e0, Sara Barber\u00e1n and Susanna Fraguas, from the Department of Genetics, Microbiology and Statistics of the\u00a0<a href=\"http:\/\/www.ub.edu\/ibub\/\" target=\"_self\" rel=\"noopener noreferrer\">Institute of Biomedicine of the University of Barcelona (IBUB)<\/a>, based at PCB,\u00a0describes for the first time the function of a signalling pathway \u2013particularly, the pathway of epidermal growth factor receptors (EGFR) &#8211; in the differentiation of the planarian digestive lineage. EGFR pathway, evolutionarily preserved, has a fundamental role when regulating the cell differentiation and proliferation in lots of organisms (such as mammals\u2019 neural stem cells) and it is over-activated in most of human cancers.\u00a0<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":53655,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49634","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>First signalling pathway of the digestive lineage in planarians is described - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/first-signalling-pathway-of-the-digestive-lineage-in-planarians-is-described\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"First signalling pathway of the digestive lineage in planarians is described - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"A scientific study made\u00a0by the researchers Francesc Cebri\u00e0, Sara Barber\u00e1n and Susanna Fraguas, from the Department of Genetics, Microbiology and Statistics of the\u00a0Institute of Biomedicine of the University of Barcelona (IBUB), based at PCB,\u00a0describes for the first time the function of a signalling pathway \u2013particularly, the pathway of epidermal growth factor receptors (EGFR) - in the differentiation of the planarian digestive lineage. 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