{"id":49600,"date":"2015-12-11T00:00:00","date_gmt":"2015-12-10T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/scientists-in-barcelona-discover-a-potential-treatment-for-cirrhosis\/"},"modified":"2020-11-18T14:55:56","modified_gmt":"2020-11-18T13:55:56","slug":"scientists-in-barcelona-discover-a-potential-treatment-for-cirrhosis","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/scientists-in-barcelona-discover-a-potential-treatment-for-cirrhosis\/","title":{"rendered":"Scientists in Barcelona discover a potential treatment for cirrhosis"},"content":{"rendered":"<p>Scientists headed by Ra\u00fal M\u00e9ndez, ICREA research professor at IRB Barcelona,\u00a0and\u00a0Mercedes Fern\u00e1ndez, at IDIBAPS,\u00a0reveal that the inhibition of CPEB4 protein may prevent the development of the abnormal blood vessels associated with cirrhosis. Pathological angiogenesis is one of the most serious complications in patients with cirrhosis and a key factor in the development and worsening of the disease.<\/p>\n<p>Cirrhosis is a chronic lesion characterised by the accumulation of scar tissue (fibrous nodules), which alters the normal structure and function of the organ. The accumulation of scar tissue impedes blood circulation in the liver, thus leading to portal hypertension (the portal vein). To relieve the pressure in the vein, collateral blood vessels develop outside the liver. The problem is then two-fold, first because the liver receives even less blood, thereby causing greater damage to the organ, and second because the blood vessels are of poor quality (pathological angiogenesis).<\/p>\n<p>\u201cHepatic cells try to repair liver lesions, but the way by which they do this turns out to be fatal for the organ. This is a loop that gets bigger and finally threatens the patient\u2019s life. Also, the collateral blood vessels form varicose veins in the oesophagus and stomach of patients with cirrhosis; these veins are fragile and have a high tendency to burst, causing heavy bleeding that is difficult to stop,\u201d explains Mercedes Fern\u00e1ndez, from IDIBAPS and co-leader of the study. \u201cThis is why a treatment that regresses and\/or prevents pathological veins\u2014which is not currently available\u2014would be efficient,\u201d she adds.<\/p>\n<p>\u00a0<\/p>\n<p><strong>A target named CPEB4<\/strong><\/p>\n<p>VEGF (vascular endothelial growth factor) is the main effector protein in the development of blood vessels. \u201cAll current drugs that aim to prevent neovascularisation are based on inhibiting VEGF or VEGF receptors, but the problem is that indiscriminate attack of this protein impairs the normal development of blood vessels, thus causing unbearable adverse effects,\u201d explains M\u00e9ndez, from IRB Barcelona.\u00a0<\/p>\n<p>In a previous study published in\u00a0Nature Medicine, M\u00e9ndez, together with researchers at the\u00a0Hospital del Mar\u00a0in Barcelona, had already discovered that CPEB proteins are involved in blood vessel development in pancreatic and brain cancer. Given the urgent need to identify new targets for pathological angiogenesis, M\u00e9ndez and Fern\u00e1ndez started collaborating to examine the role of CPEB4 in this process in the context of cirrhosis, a disease characterised by profound neovascularisation.<\/p>\n<p>\u201cThe best about the study is that we demonstrate that the development of pathological blood vessels can be stopped by interfering with CPEB4 proteins while positive vascularisation remains intact,\u201d says M\u00e9ndez. The experiments in cells\u00a0in vitro, in animal models, and in samples taken from patients with cirrhosis have revealed the molecular mechanisms through which the increase in CPEB4 favours the overexpression of VEGF in cirrhosis.<\/p>\n<p>\n\u2022\u00a0<strong>Reference article:<\/strong><br \/>\n<em>Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of VEGF and Angiogenesis in Chronic Liver Disease.<\/em>\u00a0Calderone V, Gallego J, Fernandez-Miranda G, Garcia-Pras E, Maillo C, Berzigotti A, Mejias M, Bava FA, Angulo-Urarte A, Graupera M, Navarro P, Bosch J, Fernandez M*, Mendez R*.Gastroenterology\u00a0(2015). DOI:\u00a0<a href=\"http:\/\/www.gastrojournal.org\/article\/S0016-5085%2815%2901720-5\/abstract?referrer=http%3A%2F%2Fwww.gastrojournal.org%2Farticle%2FS0016-5085%2815%2901720-5%2Fabstract\" target=\"_blank\" rel=\"noopener noreferrer\">10.1053\/j.gastro.2015.11.038<\/a><\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists from the Institute for Research in Biomedicine (<a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_000001&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_keywords%3Dirb%26_cercador_WAR_empleatsempresesportlet_tab%3D1\" target=\"_blank\" rel=\"noopener noreferrer\">IRB Barcelona<\/a>) at PCB and\u00a0the August Pi i Sunyer Biomedical Research Institute (<a href=\"http:\/\/www.idibaps.org\/en_index.html\" target=\"_blank\" rel=\"noopener noreferrer\">IDIBAPS<\/a>)\u00a0reveals a therapeutic target to prevent the development of the many abnormal blood vessels that cause gastrointestinal bleeding\u2014the main complication in cirrhosis. The results of the study have been published in the most recent issue of\u00a0Cirrhosis is the main risk factor for liver cancer. The same target may be the key to preventing and treating this condition.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":53510,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49600","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Scientists in Barcelona discover a potential treatment for cirrhosis - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/scientists-in-barcelona-discover-a-potential-treatment-for-cirrhosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists in Barcelona discover a potential treatment for cirrhosis - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Scientists from the Institute for Research in Biomedicine (IRB Barcelona) at PCB and\u00a0the August Pi i Sunyer Biomedical Research Institute (IDIBAPS)\u00a0reveals a therapeutic target to prevent the development of the many abnormal blood vessels that cause gastrointestinal bleeding\u2014the main complication in cirrhosis. The results of the study have been published in the most recent issue of\u00a0Cirrhosis is the main risk factor for liver cancer. 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