{"id":49598,"date":"2017-06-01T00:00:00","date_gmt":"2017-05-31T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/chemotargets-and-the-josep-carreras-leukemia-research-institute-sign-collaboration-agreement\/"},"modified":"2020-11-18T14:55:56","modified_gmt":"2020-11-18T13:55:56","slug":"chemotargets-and-the-josep-carreras-leukemia-research-institute-sign-collaboration-agreement","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/chemotargets-and-the-josep-carreras-leukemia-research-institute-sign-collaboration-agreement\/","title":{"rendered":"Chemotargets and the Josep Carreras Leukemia Research Institute sign collaboration agreement"},"content":{"rendered":"<p>The acute myeloid leukemia (AML) research group, directed by Dr. Ruth M. Risue\u00f1o, recently published a study in which the importance of serotonin receptor subtype 1 (HTR1) in AML was highlighted (<a href=\"http:\/\/www.nature.com\/leu\/journal\/vaop\/ncurrent\/full\/leu201752a.html\" rel=\"external noopener noreferrer\" target=\"_blank\">Etxabe et al. Leukemia 2017<\/a>). \u201cWe observed that AML cells differentially expressed HTR1 compared with healthy blood cells and the most primitive hematopoietic fraction; in fact, HTR1B expression in AML patient samples correlated with the clinical outcome\u201d, said Dr. Risue\u00f1o. \u201cBased on these results and other projects developed in the group, we discovered some active hits on HTR1 and other receptors with antileukemia effects; these represent excellent starting points for a drug discovery program and Chemotargets\u2019 platform will be of great help in this process\u201d.<\/p>\n<p>Dr. Jordi Mestres, Chemotargets\u2019 Founder &amp; CEO commented: \u201cChemotargets has developed a state-of-the-art analytics and visualization platform that integrates big data in chemistry, pharmacology, toxicology, and therapeutics, combined with novel precision modeling algorithms to predict unknown data in those areas. We are delighted to put our powerful platform to work to accelerate IJC\u2019s drug discovery efforts in the field of AML\u201d.<\/p>\n<p>\u2022 More information: <a href=\"https:\/\/www.imim.cat\/news\/252\/the-josep-carreras-leukemia-research-institute-and-chemotargets-sign-collaboration-agreement\" target=\"_blank\" rel=\"noopener noreferrer\">IMIM website [+]<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The\u00a0Josep Carreras Leukemia Research Institute\u00a0(<a href=\"http:\/\/www.carrerasresearch.org\/en\" target=\"_blank\" rel=\"noopener noreferrer\">IJC<\/a>) announced today that it has entered into a collaboration agreement with\u00a0the IMIM&#8217;s spin-off\u00a0<a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_006013&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fes%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_keywords%3Dchemotargets%26_cercador_WAR_empleatsempresesportlet_tab%3D1\" target=\"_blank\" rel=\"noopener noreferrer\">Chemotargets<\/a>, located at the Barcelona Science Park.\u00a0\u00a0The aim of the collaboration is to further understand the mechanism of action of some active hits in leukemia discovered at IJC, and exploit this information to identify new chemical entities with improved pharmacology and safety profiles using Chemotargets\u2019 precision modeling platform.\u00a0<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":53502,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49598","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - 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