{"id":49578,"date":"2016-08-29T00:00:00","date_gmt":"2016-08-28T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/sights-set-on-the-next-generation-of-shuttle-peptides-to-target-the-brain\/"},"modified":"2020-11-18T14:55:49","modified_gmt":"2020-11-18T13:55:49","slug":"sights-set-on-the-next-generation-of-shuttle-peptides-to-target-the-brain","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/sights-set-on-the-next-generation-of-shuttle-peptides-to-target-the-brain\/","title":{"rendered":"Sights set on the next generation of shuttle peptides to target the brain"},"content":{"rendered":"

Ten years ago, IRB Barcelona group leader Ernest Giralt at PCB started work on peptide shuttles to overcome the blood-brain barrier\u2014 a line of research that Dr. Meritxell Teixid\u00f3 is now in charge of. In this regard, they are one of the few expert groups worldwide in this field, which brings together chemistry, pharmacy and biomedicine. In this period, researchers at IRB Barcelona have published 15 scientific articles and hold 4 patents, thus contributing to the development of the field and becoming an international reference on this topic.<\/p>\n

The article highlights that the administration of drugs to the brain is one of the main challenges of drug development, given the significant number of patients with neurological diseases and the low efficiency of the treatments currently available. Although the barrier that protects the brain\u2014known as the blood-brain barrier (BBB)\u2014limits the capacity of drugs\u2014many with great potential\u2014to reach their target, molecular peptide vectors, known as BBB shuttles, are emerging as a promising tool to overcome this obstacle.<\/p>\n

In recent years, transporters based on peptides\u2014small proteins\u2014are attracting attention in the field due to their low production cost, small effect on immune system response, and chemical versatility compared with traditional antibodies and other larger proteins.<\/p>\n

The review article presents the BBB as a formidable obstacle but at the same time a great opportunity for the administration of drugs to the brain.<\/p>\n

\n\u2022 For further information: IRB Barcelona website [+]<\/a><\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

IRB Barcelona<\/a> scientists Benjam\u00ed Oller, Macarena S\u00e1nchez, Ernest Giralt, and Meritxell Teixid\u00f3, all from the\u00a0Peptides and Proteins Lab<\/a>\u00a0of the Chemistry and Molecular Pharmacology Programme, have written a review on the emerging field of shuttle peptides\u2014molecules that have the capacity to transport drugs across the blood-brain barrier and thus treat diseases affecting the central nervous system. The article will be featured on the cover of September\u2019s issue of\u00a0Chemical Society Reviews.<\/p>\n

\u00a0<\/p>\n","protected":false},"author":1,"featured_media":53425,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49578","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"\nSights set on the next generation of shuttle peptides to target the brain - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/sights-set-on-the-next-generation-of-shuttle-peptides-to-target-the-brain\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sights set on the next generation of shuttle peptides to target the brain - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"IRB Barcelona scientists Benjam\u00ed Oller, Macarena S\u00e1nchez, Ernest Giralt, and Meritxell Teixid\u00f3, all from the\u00a0Peptides and Proteins Lab\u00a0of the Chemistry and Molecular Pharmacology Programme, have written a review on the emerging field of shuttle peptides\u2014molecules that have the capacity to transport drugs across the blood-brain barrier and thus treat diseases affecting the central nervous system. 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