{"id":49575,"date":"2019-05-07T00:00:00","date_gmt":"2019-05-06T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/bionure-reports-successful-phase-1-study-for-lead-candidate-bn201\/"},"modified":"2020-11-18T14:55:47","modified_gmt":"2020-11-18T13:55:47","slug":"bionure-reports-successful-phase-1-study-for-lead-candidate-bn201","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/bionure-reports-successful-phase-1-study-for-lead-candidate-bn201\/","title":{"rendered":"Bionure reports successful Phase 1 Study for lead candidate BN201"},"content":{"rendered":"<p>Bionure&#8217;s main candidate\u00a0BN201\u00a0is a new chemical and first-in-class compound that demonstrated neuroprotective activity i.e. stimulation for axonal protection, remyelination and promotion of neuronal survival in preclinical models, making it an ideal candidate for facilitating neuroprotection from degenerative, ischemic, toxic and inflammatory diseases of the nervous system.\u00a0<\/p>\n<p>The results of the randomized, double-blind, placebo-controlled Phase 1 study performed in the UK in 48 healthy volunteers showed good correlation with pharmacokinetic data generated in animal studies and no drug-related safety or tolerability issues were reported in the tested dose range.\u00a0\u00a0<\/p>\n<p>Bionure\u2019s initial focus areas are Acute Optic Neuritis (AON) and Multiple sclerosis (MS), for which there still are high unmet medical needs. The current standards of care include anti-inflammatory drugs and\/or immunomodulators, both of which reduce inflammation but do not adequately protect the neurons nor repair the nerve damage. The mechanism of action of BN201 will enable it to ideally address further indications relevant for a neuroprotective agent, including other neurodegenerative disorders, cerebrovascular disease, certain ophthalmic diseases and traumatic central nervous system injuries.<\/p>\n<p>Central Nervous System drugs currently represent a substantial prescription drugmarket area with yearly sales exceeding USD 50bn, covering all major diseases including multiple sclerosis, which alone represents approximately USD 20bn. &#8220;I\u2019m delighted about the results of the Phase 1 clinical study that is a clear milestone achievement following our 15 years of research in neuroprotection. We will now prepare the implementation of a Phase 2 program to confirm the potential of BN201 to bring clinical benefits to patients\u201d, said Dr. Pablo Villoslada, scientific founder and CSO of Bionure,\u00a0\u00a0a spin-off from IDIBAPS &#8211; Hospital Clinic of the University of Barcelona and the Spanish National Council CSIC (Spain).<\/p>\n<p>&#8220;Currently there is a strong need for effective neuroprotectants and no remyelinating drug approved. Since only a handful of programs are in clinical development, this represents a great opportunity for Bionure to become a game changer in the neuroprotective market. We will now prepare a Series B financing round to fund the Phase 2 program,&#8221; added Laurent Nguyen, CEO of Bionure. BN201 is covered by Composition of Matter and Method-of-Use patents and has orphan drug designation in the EU and the US for Acute Optic Neuritis.\u00a0<\/p>\n<p>\u25ba <a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/noticies\/-\/noticia\/not_bionure-inicia-un-assaig-clinic-de-fase-1-del-seu-compost-bn201-al-regne-unit?inheritRedirect=false&amp;redirect=%2Fportal%2Fes%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_state%3Dnormal%26p_p_mode%3Dview%26p_p_col_id%3Dcolumn-1%26p_p_col_count%3D1%26_cercador_WAR_empleatsempresesportlet_keywords%3DBIONURE%26_cercador_WAR_empleatsempresesportlet_tab%3D3&amp;backURL=%2Fportal%2Fes%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_state%3Dnormal%26p_p_mode%3Dview%26p_p_col_id%3Dcolumn-1%26p_p_col_count%3D1%26_cercador_WAR_empleatsempresesportlet_keywords%3DBIONURE%26_cercador_WAR_empleatsempresesportlet_tab%3D3\" target=\"_blank\" rel=\"noopener noreferrer\">Related news [+]<\/a><\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p><a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_004156&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_keywords%3Dbionure%26_cercador_WAR_empleatsempresesportlet_tab%3D1\" target=\"_blank\" rel=\"noopener noreferrer\">Bionure<\/a>, a biotech company specialized in neuroprotection based in the Barcelona Science Park, today announces that it has successfully concluded its Phase 1 clinical study with its lead candidate\u00a0<a href=\"https:\/\/bionure.com\/lead-compound-bn201\/\" target=\"_blank\" rel=\"noopener noreferrer\">BN201<\/a>, a first-in-class compound to\u00a0treat neurodegenerative diseases such as Multiple Sclerosis (MS).\u00a0The company is now preparing a Series B funding round to finance the Phase 2 clinical program.\u00a0<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":53413,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49575","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - 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