{"id":49549,"date":"2017-07-13T00:00:00","date_gmt":"2017-07-12T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/avx-pharma-announces-initiation-of-a-phase-2-clinical-trial-of-avx-012-ophthalmic-solution-in-dry-eye-syndrome\/"},"modified":"2020-11-18T14:55:41","modified_gmt":"2020-11-18T13:55:41","slug":"avx-pharma-announces-initiation-of-a-phase-2-clinical-trial-of-avx-012-ophthalmic-solution-in-dry-eye-syndrome","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/avx-pharma-announces-initiation-of-a-phase-2-clinical-trial-of-avx-012-ophthalmic-solution-in-dry-eye-syndrome\/","title":{"rendered":"AVX pharma announces initiation of a Phase 2 Clinical Trial of AVX-012 Ophthalmic Solution in Dry Eye Syndrome"},"content":{"rendered":"<p>The company develops novel pharmacological treatments for the treatment of DED, based on the manipulation of the neural mechanisms that regulate the volume of tear fluid secreted by the lacrimal glands, and evoke the discomfort sensations elicited by ocular surface dryness, the two main mechanisms that are impaired in DED and are responsible of \u00a0the signs and symptoms observed in DED patients.<\/p>\n<p>AVX-012 Ophthalmic Solution was safe and well tolerated at all doses tested in the Phase 1 trial. &#8220;With encouraging Phase 1 data available, the initiation of this Phase 2 trial marks another important milestone for AVX-012 in Dry Eye Syndrome, a disease suffered by millions of patients that are still lacking of effective treatment options\u201d,\u00a0said Patrick Tresserras, president and CEO of AVX Pharma.<\/p>\n<p>Dry eye is a multifactorial disease of the ocular surface characterized by a loss of homeostasis of the tear film, and accompanied by ocular symptoms in which tear film instability and hyperosmolarity, ocular surface inflammation and damage, and neurosensory abnormalities play etiological roles. Prevalence reported in the USA, Australia and Europe (Spain) is approximately 5-15 %, 25% in Canada and 30-50% in Asia.\u00a0Dry Eye therapeutics market is expected to grow to $4.6 Billion by 2024.\u00a0<\/p>\n<p>AVX Pharma is a\u00a0clinical-stage\u00a0Spanish biotech ophthalmology\u00a0company\u00a0founded in 2013 in Alicante and with offices in Barcelona Science Park, focused on developing novel\u00a0therapies for Dry Eye Syndrome\u00a0based on Prof. Carlos Belmonte research on the role of temperature-sensitive neurons in tear film regulation at the Alicante Neurosciences Institute.\u00a0AVX Pharma lead product candidate AVX-012, a Small Molecule with a new Mechanism of Action,\u00a0is in clinical development for Dry Eye Syndrome.<\/p>\n<p>\n\u25ba <a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/noticies\/-\/noticia\/not_avizorex-pharma-presenta-la-sol-licitud-per-iniciar-l-assaig-clinic-del-seu-farmac-contra-la-sindrome-d-ull-sec?inheritRedirect=false&amp;redirect=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_state%3Dnormal%26p_p_mode%3Dview%26p_p_col_id%3Dcolumn-1%26p_p_col_count%3D1%26_cercador_WAR_empleatsempresesportlet_keywords%3Davx%26_cercador_WAR_empleatsempresesportlet_tab%3D3&amp;backURL=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_state%3Dnormal%26p_p_mode%3Dview%26p_p_col_id%3Dcolumn-1%26p_p_col_count%3D1%26_cercador_WAR_empleatsempresesportlet_keywords%3Davx%26_cercador_WAR_empleatsempresesportlet_tab%3D3\" target=\"_blank\" rel=\"noopener noreferrer\">Related news [+]<\/a><\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Avizorex Pharma (<a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_006370&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_keywords%3Davizorex%26_cercador_WAR_empleatsempresesportlet_tab%3D1\" target=\"_blank\" rel=\"noopener noreferrer\">AVX Pharma<\/a>), a clinical stage biopharmaceutical company with offices at Barcelona Science Park and\u00a0focused on the development of novel therapies for Dry Eye Syndrome, today announced the initiation of a Phase 2 clinical trial, evaluating the safety and efficacy of AVX-012 Ophthalmic Solution in patients with mild-to-moderate Dry Eye Syndrome, based on the concept of modulating corneal nerve activity\u00a0to stimulate basal lacrimation.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":53313,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49549","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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