{"id":49497,"date":"2019-06-20T00:00:00","date_gmt":"2019-06-19T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/a-study-from-irb-barcelona-opens-new-propsects-in-the-field-of-biocatalysers\/"},"modified":"2020-11-18T14:55:29","modified_gmt":"2020-11-18T13:55:29","slug":"a-study-from-irb-barcelona-opens-new-propsects-in-the-field-of-biocatalysers","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/a-study-from-irb-barcelona-opens-new-propsects-in-the-field-of-biocatalysers\/","title":{"rendered":"A study from IRB Barcelona opens new propsects in the field of biocatalysers"},"content":{"rendered":"

A study from the Institute for Research in Biomedicine (IRB Barcelona)\u00a0has published a study in the journal\u00a0Nature Catalysis\u00a0that describes the\u00a0reaction mechanism used by the DNAzyme 9DB1, the first structurally available catalyser formed by DNA.<\/p>\n

Until recently, it was widely assumed that DNA served to store genetic information in a stable and irreversible manner. However, in the last ten years, the discovery of the epigenetic code and the finding that nucleic acids can also catalyse certain reactions have changed this vision.\u00a0<\/p>\n

The team headed by\u00a0Modesto Orozco, head of the\u00a0Molecular Modelling and Bioinformatics<\/a>\u00a0Lab at IRB Barcelona, found that this DNAzyme catalyses RNA ligation through a similar mechanism to that used by natural enzymes.<\/p>\n

The conclusion drawn by the study may lead to improvements in current catalysers and in the design of novel biocatalysers formed by DNA. Indeed, given that DNAzymes can carry out a variety of reactions on messenger RNA and can trigger the silencing of genes, they are being developed for diagnostic and biomedical applications.\u00a0<\/p>\n

\u201cThe role of DNAzymes as catalysers is of great interest since they are easier to synthesise than proteins and RNA molecules, as well as being more stable and less expensive. However, to date, the catalytic mechanism used by DNAzymes was unknown, as were the differences between catalysers made of DNA and RNA or the protein enzymes,\u201d says\u00a0Orozco, senior professor at the University of Barcelona.<\/p>\n

\u25ba Reference article:<\/strong>\u00a0Juan Aranda, Montserrat Terrazas, Hansel G\u00f3mez, N\u00faria Villegas i\u00a0Modesto Orozco. “An artificial DNAzyme RNA ligase shows a reaction mechanism resembling that of cellular polymerases<\/a>“.\u00a0Nature Catalysis\u00a0(2019) DOI:\u00a010.1038\/s41929-019-0290-y<\/p>\n

\u25ba More information: IRB Barcelona website [+]<\/a><\/strong><\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

Modesto Orozco\u2019s lab at IRB Barcelona<\/a> in PCB has published a study on the reaction mechanism of DNAzymes in Nature Catalysis. DNAzymes, which are catalysers formed by DNA, have applications in biomedicine and biotechnology. These research results will contribute to advances in the design and improvement of catalysers for therapeutic purposes.<\/p>\n

\u00a0<\/p>\n","protected":false},"author":1,"featured_media":53151,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49497","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"\nA study from IRB Barcelona opens new propsects in the field of biocatalysers - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/a-study-from-irb-barcelona-opens-new-propsects-in-the-field-of-biocatalysers\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A study from IRB Barcelona opens new propsects in the field of biocatalysers - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Modesto Orozco\u2019s lab at IRB Barcelona in PCB has published a study on the reaction mechanism of DNAzymes in Nature Catalysis. 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