{"id":49490,"date":"2019-02-28T00:00:00","date_gmt":"2019-02-27T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/urea-powered-nanomotors-a-promising-therapy-for-bladder-cancer\/"},"modified":"2020-11-18T14:55:27","modified_gmt":"2020-11-18T13:55:27","slug":"urea-powered-nanomotors-a-promising-therapy-for-bladder-cancer","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/urea-powered-nanomotors-a-promising-therapy-for-bladder-cancer\/","title":{"rendered":"Urea-powered nanomotors a promising therapy for bladder cancer"},"content":{"rendered":"

The nanomotors carry anti-FGFR3 on their outer surface, an antibody that not only enables cancerous cells to be specifically targeted, but also inhibits the fibroblast growth factor signaling pathway, suppressing tumor growth. Crucially, the fuel that gives the nanomotors the capability of autonomous motion is urea, which is present at high concentrations in the bladder \u2013 making these particular nanomotors a promising avenue for this particular cancer.<\/p>\n

\u201cOur antibody-loaded nanomotors were able to \u2018swim\u2019 in both simulated and real urine,\u201d says ICREA research professor Samuel Sanchez, who heads IBEC\u2019s Smart Nano-Bio-Devices group. \u201cWe noticed a better suppression of the bladder cancer cells than when we used nanomotors without the antibody modification, and even more when compared with passive nanoparticles, which could arise from both the local ammonia production and the therapeutic effect of anti-FGFR3.\u201d<\/p>\n

Bladder cancer is the ninth most common cancer worldwide and presents a high survival rate but serious recurrence levels, demanding an improvement in existing therapies.<\/p>\n

Nanomotors are a promising way to specifically target tumor tissues, enhancing the efficacy of cancer treatment and minimizing side effects. \u201cFuture studies using antibody-modified nanomotors that carry an imaging agent may open avenues to more efficient cancer diagnosis or therapies,\u201d says Ana Hortela\u0303o, PhD student and first author of the paper.<\/p>\n

\n\u25ba Reference article:<\/strong> Ana C. Hortel\u00e3o, Rafael Carrascosa, Nerea Murillo-Cremaes, Tania Pati\u00f1o, and Samuel S\u00e1nchez (2018). “Targeting 3D Bladder Cancer Spheroids with Urease-Powered Nanomotors<\/a>“. ACS Nano, DOI:\u00a010.1021\/acsnano.8b06610.<\/p>\n

\u25ba More information:\u00a0I<\/a>BEC website [+]<\/a><\/strong><\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

The\u00a0S<\/a>mart Nano-Bio-Devices group\u00a0at the Institute for Bioengineering of Catalonia\u00a0(IBEC<\/a>) in the Barcelona Science Park have published a paper describing nanomotors that can attack 3D bladder cancer spheroids\u00a0in vitro.<\/em> The study reveals that\u00a0nanomotors are a promising way to specifically target tumor tissues, enhancing the efficacy of cancer treatment and minimizing side effects.<\/p>\n

\u00a0<\/p>\n","protected":false},"author":1,"featured_media":53127,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-49490","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"\nUrea-powered nanomotors a promising therapy for bladder cancer - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/urea-powered-nanomotors-a-promising-therapy-for-bladder-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Urea-powered nanomotors a promising therapy for bladder cancer - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"The\u00a0Smart Nano-Bio-Devices group\u00a0at the Institute for Bioengineering of Catalonia\u00a0(IBEC) in the Barcelona Science Park have published a paper describing nanomotors that can attack 3D bladder cancer spheroids\u00a0in vitro. 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