{"id":48913,"date":"2014-05-21T00:00:00","date_gmt":"2014-05-20T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/ibub-research-group-describes-a-key-gene-in-early-brain-regeneration-in-planarians\/"},"modified":"2020-11-18T14:54:07","modified_gmt":"2020-11-18T13:54:07","slug":"ibub-research-group-describes-a-key-gene-in-early-brain-regeneration-in-planarians","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/ibub-research-group-describes-a-key-gene-in-early-brain-regeneration-in-planarians\/","title":{"rendered":"IBUB research group describes a key gene in early brain regeneration in planarians"},"content":{"rendered":"

”<\/p>\n

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\t\t\tTissue regeneration is a highly complex process studied by international research groups in different animal models (planarian, zebra fish, newt, axoloti, Hydra, etc.). The scientific community has long postulated that the nervous system may play a determinant role in the process of regeneration in animals. The new study strengthen the hypothesis suggested about the key role that the nervous system plays in metazoan regeneration. Furthermore, if defines a hypothetic model in which early brain regeneration is crucial to guarantee anterior regeneration in planarians. In other words, if brain is not well-regenerated, the global regeneration programme is stopped. <\/p>\n

The planarian Schmidtea mediterranea are flatworms with bilateral symmetry used as models in the research on cell regeneration and stem cells. The paper describes the first study that relates the gene egr-4 \u2014member of a gene family that codifies transcription factors and regulate the activity of other genes\u2014 with the process of neurogenesis in planarians. <\/p>\n

Professor Francesc Cebri\u00e0, leader of the scientific study, affirms that “in other animals, genes egr are activated in immediate response processes such as inflammation, wound healing and stress”. “Moreover \u2014he points out\u2014, some of these genes also play a major role in the development of the nervous system”. The genes egr control different processes, from cell proliferation to cell survival or cell differentiation. In the case of planarians, the gene egr-4 seems to perform an early control of cell proliferation as a response to amputation, and then be involved in the early differentiation of brain during regeneration. Cebri\u00e0 highlights that “as there are genes which are similar to egr-4 in other lineages \u2014for instance the human species\u2014, this function may be particularly interesting to understand the process of regeneration in metazoans”. <\/p>\n

For further information [+]<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"

According to a paper published in the prestigious journal Development (doi:10.1242\/dev.101345<\/a>), the gene egr-4 may play a key role in early brain regeneration in planarians \u2014a group of invertebrates used to study of the genetics of development. 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