{"id":48716,"date":"2013-12-19T00:00:00","date_gmt":"2013-12-18T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/the-journal-of-immunology-highlights-an-article-of-the-research-group-on-macrophage-biology\/"},"modified":"2020-11-18T14:53:38","modified_gmt":"2020-11-18T13:53:38","slug":"the-journal-of-immunology-highlights-an-article-of-the-research-group-on-macrophage-biology","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/the-journal-of-immunology-highlights-an-article-of-the-research-group-on-macrophage-biology\/","title":{"rendered":"\u2018The Journal of Immunology&#8217; highlights an article of the Research Group on Macrophage Biology"},"content":{"rendered":"<p>&#8221;<\/p>\n<div class=\"col-sm-6 detall-noticia-imatges\">\n<div class=\"row\">\n<div class=\"item active one-image\">\n\t\t\t\t\t\t<a class=\"icon-search\" href='http:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2020\/11\/1387814868214.jpg'><\/a><br \/>\n\t\t\t\t\t\t<img src='http:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2020\/11\/1387814868214.jpg' \/>\n\t\t\t\t\t<\/div><\/div><\/div>\n<p>\t\t\tMutations in TREX1 gene, the most abundant exonuclease in mammalian cells, are linked to the development of some autoimmune diseases, such as the systemic lupus erythematosus. The expert Selma Pereira Lopes is the first author of the article, which reveals that TREX1 may negatively regulate pathways in macrophages that promote inflammation and predispose individuals toward the development of autoimmunity. <\/p>\n<p> In the study, the inflammatory phenotype was characterized in tissues and cells of the immune systems in mice Trex1-\/- (withoutTREX1). Results prove an increase of proinflammatory gene expression in several organs, included the brain. <\/p>\n<p> The Consolidated Research Group on Macrophage Biology. Regulation of Gene Expression, led by Professor Antonio Celada, focuses its activity on studying the molecular mechanims involved in macrophage proliferation, activation, differentiation and entry in apoptosis. Macrophages are key cells involved in immune response (destroy bacteria, virus, parasites, tumour cells, etc.). <\/p>\n<p><p> <a>For further information [+] <\/a>    <\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00ab<a>The Exonuclease Trex1 Restrains Macrophage Proinflammatory Activation<\/a>\u00bb is the title of the article that the editors of the latest issue of The Journal of Immunology selected as one of the best studies. It is signed by experts Selma Pereira Lopes, Gl\u00f2ria Sans Fons, Jorge Lloberas and Antonio Celada, from the Department of Physiology and Immunology of the Faculty of Biology and members of the <a>Consolidated Research Group on Macrophage Biology. Regulation of Gene Expression<\/a>, based in the Parc Cient\u00edfic de Barcelona.The article is also signed by Teja Celhar and Anna-Marie Fairhurst, from the Singapore Immunology Network (SIgN). <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-48716","post","type-post","status-publish","format-standard","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u2018The Journal of Immunology&#039; highlights an article of the Research Group on Macrophage Biology - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/the-journal-of-immunology-highlights-an-article-of-the-research-group-on-macrophage-biology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u2018The Journal of Immunology&#039; highlights an article of the Research Group on Macrophage Biology - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"\u00abThe Exonuclease Trex1 Restrains Macrophage Proinflammatory Activation\u00bb is the title of the article that the editors of the latest issue of The Journal of Immunology selected as one of the best studies. It is signed by experts Selma Pereira Lopes, Gl\u00f2ria Sans Fons, Jorge Lloberas and Antonio Celada, from the Department of Physiology and Immunology of the Faculty of Biology and members of the Consolidated Research Group on Macrophage Biology. 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