{"id":48362,"date":"2013-03-19T00:00:00","date_gmt":"2013-03-18T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/desxifrat-un-mecanisme-clau-en-la-virulencia-de-les-infeccions-fungiquesto-translate\/"},"modified":"2020-11-18T14:53:05","modified_gmt":"2020-11-18T13:53:05","slug":"desxifrat-un-mecanisme-clau-en-la-virulencia-de-les-infeccions-fungiquesto-translate","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/desxifrat-un-mecanisme-clau-en-la-virulencia-de-les-infeccions-fungiquesto-translate\/","title":{"rendered":"Desxifrat un mecanisme clau en la virul\u00e8ncia de les infeccions f\u00fangiquesTO TRANSLATE >>>"},"content":{"rendered":"

”<\/p>\n

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\n\t\t\t\t\t\t<\/a>
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\t\t\tDescobertes el 1957 pels experts Marghoses i Vallee, les metal\u00b7lotione\u00efnes (MT) s\u00f3n unes prote\u00efnes de baix pes molecular que contenen molts residus de l’amino\u00e0cid ciste\u00efna. Gr\u00e0cies a aquesta estructura, poden enlla\u00e7ar ions met\u00e0l\u00b7lics i actuar com a agents quelants \u2014compostos que capturen metalls\u2014 per captar i distribuir metalls d’inter\u00e8s biol\u00f2gic (coure, zinc, cadmi, mercuri, entre d’altres). Les MT s\u00f3n prote\u00efnes molt heterog\u00e8nies i polim\u00f2rfiques, i es troben en tot tipus d’organismes (procariotes, fongs, vegetals, vertebrats, etc.), on faciliten el proc\u00e9s de destoxificaci\u00f3 o eliminaci\u00f3 de metalls t\u00f2xics i ajuden a modular la resposta fisiol\u00f2gica de l’organisme davant la car\u00e8ncia o l’exc\u00e9s de metalls. <\/p>\n

En recerques pr\u00e8vies, s’havien identificat unes prote\u00efnes produ\u00efdes pel fong C. neoformans en resposta a nivells elevats de coure. \u00abPer primer cop, el nou treball constata que aquestes prote\u00efnes s\u00f3n metal\u00b7lotione\u00efnes, i que s\u00f3n factors cr\u00edtics per a la colonitzaci\u00f3 i la virul\u00e8ncia del patogen\u00bb, explica la catedr\u00e0tica S\u00edlvia Atrian, <\/p>\n

Ara, aquest treball revela que l’expressi\u00f3 g\u00e8nica de les MT del C. neoformans s’activa durant la infecci\u00f3 pulmonar. Tal com explica la investigadora Anna Espart, \u00abun cop el fong \u00e9s capa\u00e7 d’infectar els pulmons, els macr\u00f2fags, entre altres estrat\u00e8gies de defensa, creen un ambient ric en coure per lluitar contra la infecci\u00f3. En aquest entorn amb nivells alts de coure, s’activa la s\u00edntesi de les MT del fong, que s\u00f3n capaces de capturar el coure i permetre, aix\u00ed, l’aven\u00e7 de la infecci\u00f3 en un ambient hostil per al patogen\u00bb. <\/p>\n","protected":false},"excerpt":{"rendered":"

Les metal\u00b7lotione\u00efnes, unes prote\u00efnes capaces de capturar ions met\u00e0l\u00b7lics, s\u00f3n un factor clau per a la virul\u00e8ncia del fong Cryptococcus neoformans, un patogen que causa greus infeccions a persones amb la immunitat alterada (malalts de sida, receptors de trasplantaments, etc.). Aquesta \u00e9s una de les conclusions principals d’un estudi publicat a la revista Cell, Host & Microbe en el qual han participat les investigadores S\u00edlvia Atrian i Anna Espart, del Departament de Gen\u00e8tica i de l’Institut de Biomedicina de la UB (IBUB) \u2013ubicat al Parc Cient\u00edfic de Barcelona\u2013 adscrits al campus d’excel\u00b7l\u00e8ncia internacional BKC. <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-48362","post","type-post","status-publish","format-standard","category-uncategorized"],"acf":[],"yoast_head":"\nDesxifrat un mecanisme clau en la virul\u00e8ncia de les infeccions f\u00fangiquesTO TRANSLATE >>> - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/desxifrat-un-mecanisme-clau-en-la-virulencia-de-les-infeccions-fungiquesto-translate\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Desxifrat un mecanisme clau en la virul\u00e8ncia de les infeccions f\u00fangiquesTO TRANSLATE >>> - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Les metal\u00b7lotione\u00efnes, unes prote\u00efnes capaces de capturar ions met\u00e0l\u00b7lics, s\u00f3n un factor clau per a la virul\u00e8ncia del fong Cryptococcus neoformans, un patogen que causa greus infeccions a persones amb la immunitat alterada (malalts de sida, receptors de trasplantaments, etc.). 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