{"id":47336,"date":"2004-05-25T00:00:00","date_gmt":"2004-05-24T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/new-evidence-on-the-mechanisms-responsible-for-neuronal-migration-and-axonal-development-in-the-central-nervous-system\/"},"modified":"2020-11-18T14:51:25","modified_gmt":"2020-11-18T13:51:25","slug":"new-evidence-on-the-mechanisms-responsible-for-neuronal-migration-and-axonal-development-in-the-central-nervous-system","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/new-evidence-on-the-mechanisms-responsible-for-neuronal-migration-and-axonal-development-in-the-central-nervous-system\/","title":{"rendered":"New evidence on the mechanisms responsible for neuronal migration and axonal development in the central nervous system"},"content":{"rendered":"

Un nou estudi que es publica avui a la revista Current Biology<\/a>, aporta nous coneixements sobre els mecanismes de senyalitzaci\u00f3 intracel\u00b7lular que regulen l’activitat de la MAP1B. Concretament, l’estudi conclou que aquesta prote\u00efna es troba sota la cascada de senyalitzaci\u00f3 intracel\u00b7lular indu\u00efda per una prote\u00efna anomenada Netrina-1, a la vegada implicada en migraci\u00f3 i desenvolupament axonal. El repertori de les funcions de la Netrina-1 encara no es coneix en la seva totalitat, per\u00f2 dades recents indiquen que, a m\u00e9s de la seva participaci\u00f3 en el desenvolupament neuronal, la Netrina-1 participa en la migraci\u00f3 de c\u00e8l\u00b7lules epitelials del p\u00e0ncreas i en la aparici\u00f3 d’alguns tumors. <\/p>\n

Les conclusions d’aquest treball poden ser de rellev\u00e0ncia per al coneixement molecular de determinades malalties neurol\u00f2giques i s\u00edndromes que, en humans, venen donant-se amb una incid\u00e8ncia creixent, i que presenten malformacions del sistema nervi\u00f3s central, com la acallosis neocortical, en qu\u00e8 es d\u00f3na una p\u00e8rdua de les fibres d’associaci\u00f3 interhemisf\u00e8rica coneguda com a cos call\u00f3s. <\/p>\n

L’estudi l’han dut a terme investigadors del Grup de Recerca en Neurobiologia del Desenvolupament i de la Regeneraci\u00f3 Cel\u00b7lular<\/a> de l’Insitut de Recerca Biom\u00e8dica del Parc Cient\u00edfic de Barcelona (IRBB-PCB)<\/a>, sota la direcci\u00f3 del catedr\u00e0tic del departament de Biologia Cel\u00b7lular de la UB<\/a> Eduardo Soriano i del professor titular del mateix departament Jos\u00e9 A. Del R\u00edo, en coordinaci\u00f3 amb un grup d’investigaci\u00f3 del Centro de Biolog\u00eda Molecular Severo Ochoa del CSIC-UAM<\/a>, dirigit per Jes\u00fas Avila de Grado i Christian Gonzalez-Billault. <\/p>\n

En aquest estudi els cient\u00edfics han trobat, en primer lloc, que la Netrina-1 regula la fosforilaci\u00f3 de la MAP1B en una cascada de senyalitzaci\u00f3 intracel\u00b7lular que dep\u00e8n essencialment de les kinasses GSK3 i CDK5. <\/p>\n

En segon lloc, l’estudi tamb\u00e9 mostra que les neurones embrion\u00e0ries obtingudes de ratolins deficients en la prote\u00efna MAP1B no responen a la Netrina 1 in vitro. <\/p>\n

En tercer lloc, es demostra que els ratolins d’expressi\u00f3 nul\u00b7la del gen MAP1B presenten importants anormalitats en el sistema nervi\u00f3s central, com ara abs\u00e8ncia de cos call\u00f3s. Aquests ratolins tamb\u00e9 mostren greus alteracions en les connexions entre l’escor\u00e7a cerebral i el t\u00e0lem. Aquestes malformacions s\u00f3n similars a les qu\u00e8 es mostren en ratolins deficients en Netrina-1 o en el seu receptor, l’anomenat deleted incolorectal carcinoma (DDC) <\/p>\n","protected":false},"excerpt":{"rendered":"

During the first stages of embryonic development, the stem cells become differentiated as tissues of distinct parts of the human body. During this process, it is known that in the brain, Microtubule Associated Protein 1B (MAP1B) plays a crucial role in neuronal migration and axonal movement. 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