{"id":47161,"date":"2011-04-13T00:00:00","date_gmt":"2011-04-12T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/recycling-within-amyloid-beta-fibrils-might-be-a-clue-to-the-cause-of-alzheimers-disease\/"},"modified":"2020-11-18T14:51:09","modified_gmt":"2020-11-18T13:51:09","slug":"recycling-within-amyloid-beta-fibrils-might-be-a-clue-to-the-cause-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/recycling-within-amyloid-beta-fibrils-might-be-a-clue-to-the-cause-of-alzheimers-disease\/","title":{"rendered":"Recycling within amyloid-beta fibrils might be a clue to the cause of Alzheimer’s disease"},"content":{"rendered":"

”<\/p>\n

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\n\t\t\t\t\t\t<\/a>
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\t\t\tThese findings suggest that recycling could be a source of small non-fibrillar A\u03b2 aggregates, which are believed to be responsible for the neurodegeneration observed in AD. The authors of this study, experts in protein structure and aggregation at IRB Barcelona, located at the barcelona scientific Park\u2013 and other research centers, led by the ICREA researcher N\u00e0talia Carulla, believe that modulation of fibril recycling may lead to the development of new therapeutic approaches to treat this disease. <\/p>\n

More information<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"

A research study, published yesterday (Tuesday, 12 April 2011) in the Journal of the American Chemical Society (JACS), demonstrates that the aggregation of amyloid-beta (A\u03b2) proteins into amyloid fibrils characteristic of Alzheimer’s disease (AD) is not irreversible, as previously thought. The A\u03b2 protein molecules that comprise the fibrils are continuously detaching from and re-attaching to the fibrils, resulting in molecular recycling.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-47161","post","type-post","status-publish","format-standard","category-uncategorized"],"acf":[],"yoast_head":"\nRecycling within amyloid-beta fibrils might be a clue to the cause of Alzheimer's disease - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/recycling-within-amyloid-beta-fibrils-might-be-a-clue-to-the-cause-of-alzheimers-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Recycling within amyloid-beta fibrils might be a clue to the cause of Alzheimer's disease - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"A research study, published yesterday (Tuesday, 12 April 2011) in the Journal of the American Chemical Society (JACS), demonstrates that the aggregation of amyloid-beta (A\u03b2) proteins into amyloid fibrils characteristic of Alzheimer's disease (AD) is not irreversible, as previously thought. 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