{"id":45572,"date":"2018-06-21T00:00:00","date_gmt":"2018-06-20T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/researchers-find-the-genetic-basis-psychiatric-disorders-have-in-common\/"},"modified":"2020-11-18T14:48:21","modified_gmt":"2020-11-18T13:48:21","slug":"researchers-find-the-genetic-basis-psychiatric-disorders-have-in-common","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/researchers-find-the-genetic-basis-psychiatric-disorders-have-in-common\/","title":{"rendered":"Researchers find the genetic basis psychiatric disorders have in common"},"content":{"rendered":"<p>The new study gathers data on millions of common genetic variants in more than 800,000 people \u2500among patients and healthy volunteers\u2500 which could be risk factors in 25 neurological and psychiatric disorders (schizophrenia, autism, bipolar disorder, major depression, ADHD, migraine, Alzheimer\u2019s, etc.).\u00a0<\/p>\n<p>This study is opening new frontiers in research on pathologies affecting the brain, and goes further from describing risk factors of genetic interest in the field of psychiatry. For the first time, research shapes the genetic basis psychiatric and non-psychiatric neurological disorders have in common (such as Alzheimer\u2019s, Parkinson\u2019s, migraine, etc.) and it broadens the interest focus on personality traits which are not regarded as clinical disorders (emotional instability, etc.) and cognitive parameters (school performance, for instance).<\/p>\n<p>Experts focused the analysis on genetic variants that are common among the general population \u2013present in more than 1 % of the individuals- but which can lead to psychiatric or neurological disorders in some combinations. The studied variants are those affecting changes in an only DNA nucleotide (SNPs), which are more abundant in the human genome.<\/p>\n<p>According to the researcher Bru Cormand, head of the UB Research Group on Neurogenetics and member of IBUB\u00a0\u00a0and the Rare Diseases Networking Biomedical Centre (<a href=\"http:\/\/www.ciberer.es\/\" target=\"_self\" rel=\"noopener noreferrer\">CIBERER<\/a>) and the Research Institute Sant Joan de D\u00e9u (<a href=\"http:\/\/www.fsjd.org\/ca\/irsjd_146921\" target=\"_self\" rel=\"noopener noreferrer\">IRSJD<\/a>),\u00a0\u201cthis study enables us determining the weight common genetic variants in the etiology of brain diseases: that is, describing the genetic architecture of these diseases and separating the shared genetic basis of each disorder\u2019s specificity\u201d.\u00a0<\/p>\n<p><strong><span style=\"font-size:16px\">Psychiatric disorders: a strong genetic basis in common<\/span><\/strong><\/p>\n<p>The study proves there is a strong genetic correlation between schizophrenia, autism, bipolar disorder, major depression and attention deficit\/hyperactivity disorder (ADHD). However, it also reveals there is not an important overlapping between genetic risk factors in psychiatric disorders and the other neurological pathologies.<\/p>\n<p>\u201cSome neurological disorders \u2013says Bru Cormand- such as epilepsy, ictus, multiple sclerosis, Parkinson\u2019s and Alzheimer\u2019s, have genetic bases which are different from each other and other psychiatric disorders. The only exception is migraine, a neurological disorder which shares genetics with several psychiatric disorders (such as ADHD, major depression or Tourette syndrome)\u201d.<br \/>\n\u00a0<\/p>\n<p>\u25ba<strong>Reference article:<\/strong>\u00a0V. Anttila et al., \u201c<a href=\"http:\/\/science.sciencemag.org\/content\/360\/6395\/eaap8757\" target=\"_blank\" rel=\"noopener noreferrer\">Analysis of shared heritability in common disorders of the brain<\/a>\u201d,\u00a0Science, DOI:10.1126\/science.aap875, 2018.<\/p>\n<p>\u25ba<strong>\u00a0More information on <a href=\"http:\/\/www.ub.edu\/web\/ub\/en\/menu_eines\/noticies\/2018\/06\/043.html?\" target=\"_blank\" rel=\"noopener noreferrer\">UB website [+]<\/a><\/strong><\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Psychiatric disorders share a great genetic subsceptibility, while non-psychiatric neurological disorders \u2013such as Alzheimer\u2019s and Parkinson\u2019s- have a more specific genetic, according to an article the journal\u00a0Science\u00a0has published. The work is the most ambitious and extense on shared genetic factors in brain disorders. In this multicentre study\u00a0\u2013driven by Verneri Anttila, Aiden Corvi and Ben Neale from the <a href=\"http:\/\/cbs.fas.harvard.edu\/science\/connectome-project\/brainstorm-consortium\" target=\"_blank\" rel=\"noopener noreferrer\">Brainstorm Consortium<\/a>\u2013 participate\u00a0the lecturers Bru Cormand and Raquel Rabionet, from the\u00a0<a href=\"http:\/\/www.ub.edu\/biologia\/\" target=\"_self\" rel=\"noopener noreferrer\">Faculty of Biology<\/a>\u00a0and\u00a0members of the\u00a0<a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_002730&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fca%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_keywords%3Dibub%26_cercador_WAR_empleatsempresesportlet_tab%3D1\" target=\"_blank\" rel=\"noopener noreferrer\">Institute of Biomedicine of the UB (IBUB<\/a>)\u00a0in the Barcelona Science Park,\u00a0among more than 500 experts from around the world.\u00a0<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":51583,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-45572","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Researchers find the genetic basis psychiatric disorders have in common - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/researchers-find-the-genetic-basis-psychiatric-disorders-have-in-common\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Researchers find the genetic basis psychiatric disorders have in common - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Psychiatric disorders share a great genetic subsceptibility, while non-psychiatric neurological disorders \u2013such as Alzheimer\u2019s and Parkinson\u2019s- have a more specific genetic, according to an article the journal\u00a0Science\u00a0has published. The work is the most ambitious and extense on shared genetic factors in brain disorders. In this multicentre study\u00a0\u2013driven by Verneri Anttila, Aiden Corvi and Ben Neale from the Brainstorm Consortium\u2013 participate\u00a0the lecturers Bru Cormand and Raquel Rabionet, from the\u00a0Faculty of Biology\u00a0and\u00a0members of the\u00a0Institute of Biomedicine of the UB (IBUB)\u00a0in the Barcelona Science Park,\u00a0among more than 500 experts from around the world.\u00a0 \u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pcb.ub.edu\/en\/researchers-find-the-genetic-basis-psychiatric-disorders-have-in-common\/\" \/>\n<meta property=\"og:site_name\" content=\"Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"article:published_time\" content=\"2018-06-20T23:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-18T13:48:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2018\/06\/16057059495fb520dd43da1.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"adminpcb\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"adminpcb\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/researchers-find-the-genetic-basis-psychiatric-disorders-have-in-common\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/researchers-find-the-genetic-basis-psychiatric-disorders-have-in-common\\\/\"},\"author\":{\"name\":\"adminpcb\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/d13cab05cd0a75b17fddca8496481021\"},\"headline\":\"Researchers find the genetic basis psychiatric disorders have in common\",\"datePublished\":\"2018-06-20T23:00:00+00:00\",\"dateModified\":\"2020-11-18T13:48:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/researchers-find-the-genetic-basis-psychiatric-disorders-have-in-common\\\/\"},\"wordCount\":386,\"image\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/researchers-find-the-genetic-basis-psychiatric-disorders-have-in-common\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2018\\\/06\\\/16057059495fb520dd43da1.jpeg\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/researchers-find-the-genetic-basis-psychiatric-disorders-have-in-common\\\/\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/researchers-find-the-genetic-basis-psychiatric-disorders-have-in-common\\\/\",\"name\":\"Researchers find the genetic basis psychiatric disorders have in common - 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