{"id":45570,"date":"2019-04-24T00:00:00","date_gmt":"2019-04-23T23:00:00","guid":{"rendered":"http:\/\/www.pcb.ub.edu\/characterisation-of-the-structure-and-function-of-a-member-of-the-l-amino-acid-transporter-lat-family\/"},"modified":"2020-11-18T14:48:21","modified_gmt":"2020-11-18T13:48:21","slug":"characterisation-of-the-structure-and-function-of-a-member-of-the-l-amino-acid-transporter-lat-family","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/characterisation-of-the-structure-and-function-of-a-member-of-the-l-amino-acid-transporter-lat-family\/","title":{"rendered":"Characterisation of the structure and function of a member of the L-Amino acid Transporter (LAT) family"},"content":{"rendered":"<p>In humans, there are more than 50 types of amino acid transporters, which are responsible for the cellular uptake of amino acids and for regulating the intra- and extra-cellular balance of these molecules. Mutations in these transporters are associated with a variety of diseases. However, in spite of the importance of these molecules, little is known about how they work. Scientists at the Institute for Research in Biomedicine (IRB Barcelona) have now characterised the structure of a member of the\u00a0LAT family.<\/p>\n<p>LATs form a family that includes various kinds of amino acid transporter and even even members in bacteria. Mutated LATs are associated with conditions as diverse as autism, age-related hearing loss, cystinuria and lysinuric protein intolerance.<\/p>\n<p>Published in the journal\u00a0Nature Communications, this study has focused on\u00a0BasC,\u00a0a LAT present in bacteria. \u201cWe have used BasC as a model because it shows structural and functional similarity to LATs in humans,\u201d explains Manuel Palac\u00edn, head of the\u00a0<a href=\"https:\/\/www.irbbarcelona.org\/es\/research\/amino-acid-transporters-and-disease\">Amino Acid Transporters and Disease Lab<\/a>\u00a0at IRB Barcelona.\u00a0<\/p>\n<p>y analysing the structure and function of BasC, the first authors of this work,\u00a0Ekaitz Errasti-Murugarren,Joana Fortand\u00a0Paola Bartoccioni, postdoctoral fellows at IRB Barcelona, have identified the site at which amino acids bind to LATs and the mechanism underlying the interaction at both sides of the cell membrane.<\/p>\n<p>\u201cKnowing how LATs recognise the amino acids to be transported into the cell allows us to better understand their function and to decipher the molecular defects associated with various conditions. This knowledge will then help us to develop potential treatments,\u201d comments\u00a0Palac\u00edn, full professor at the Faculty of Biology at the University of Barcelona, and head of unit U731 of the CIBERER.<\/p>\n<p>In this collaboration between IRB Barcelona, CIBERER, IBMB-CSIC and BSC-CNS, the researchers have characterised the structure of BasC by means of X-ray crystallography and using an antibody against this transporter. \u201cThe BasC antibodies that we developed provide an excellent tool through which to study the function of this transporter,\u201d adds\u00a0Palac\u00edn.\u00a0<\/p>\n<p>\n<strong>\u25ba Reference article:\u00a0<\/strong>Ekaitz Errasti-Murugarren, Joana Fort, Paola Bartoccioni, Luc\u00eda D\u00edaz, Els Pardon, Xavier Carpena, Meritxell Espino-Guarch, Antonio Zorzano, Christine Ziegler, Jan Steyaert, Juan Fern\u00e1ndez-Recio, Ignacio Fita and Manuel Palac\u00edn. &#8220;<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-09837-z\" style=\"font-weight: 200\" target=\"_blank\" rel=\"noopener noreferrer\">L-Amino acid Transporter structure and molecular bases for the asymmetry of substrate interaction<\/a>&#8220;. Nature Communications(2019) doi:10.1038\/s41467-019-09837-z<\/p>\n<p><strong>\u25ba More information:\u00a0<\/strong><a href=\"https:\/\/www.irbbarcelona.org\/en\/news\/characterisation-of-the-structure-and-function-of-a-member-of-the-l-amino-acid-transporter-lat\" target=\"_blank\" rel=\"noopener noreferrer\">IRB Barcelona website [+]<\/a><\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists at the Institute for Research in Biomedicine (<a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_000001&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fes%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_mode%3Dview%26_cercador_WAR_empleatsempresesportlet_keywords%3Dirb%26_cercador_WAR_empleatsempresesportlet_tab%3D1\" target=\"_blank\" rel=\"noopener noreferrer\">IRB Barcelona<\/a>)\u00a0in the Barcelona Science Park and the\u00a0CIBER of Rare Diseases (CIBERER)\u00a0\u2013 in collaboration with\u00a0the\u00a0Institute of Molecular Biology of Barcelona (<a href=\"http:\/\/www.pcb.ub.edu\/portal\/en\/cerca?p_p_id=cercador_WAR_empleatsempresesportlet&amp;p_p_lifecycle=0&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1&amp;p_p_col_count=1&amp;_cercador_WAR_empleatsempresesportlet_jspPage=%2Fhtml%2Fcommon%2Fdetall-empresa.jsp&amp;_cercador_WAR_empleatsempresesportlet_empresaId=ENT_000131&amp;_cercador_WAR_empleatsempresesportlet_redirect=%2Fportal%2Fes%2Fcerca%3Fp_p_id%3Dcercador_WAR_empleatsempresesportlet%26p_p_lifecycle%3D0%26p_p_state%3Dnormal%26p_p_mode%3Dview%26p_p_col_id%3Dcolumn-1%26p_p_col_count%3D1%26_cercador_WAR_empleatsempresesportlet_keywords%3DInstitut%2Bde%2BBiomedicina%2Bde%2Bla%2BUniversitat%2Bde%2BBarcelona%2B%2528IBUB%2529%26_cercador_WAR_empleatsempresesportlet_tab%3D1\" target=\"_blank\" rel=\"noopener noreferrer\">IBMB-CSIC<\/a>) at PCB,\u00a0and the Barcelona Supercomputing Center-Centro Nacional de Supercomputaci\u00f3n (<a href=\"https:\/\/www.bsc.es\/\" target=\"_blank\" rel=\"noopener noreferrer\">BSC-CNS<\/a>) \u2013\u00a0have now characterised the structure of a member of the\u00a0LAT family.\u00a0Mutations in L-amino acid transporters (LATs) can lead to a wide range of conditions, such as autism, hearing loss and aminoacidurias. The work\u00a0has been published\u00a0in the journal\u00a0Nature Communications.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"author":1,"featured_media":51577,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-45570","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Characterisation of the structure and function of a member of the L-Amino acid Transporter (LAT) family - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/characterisation-of-the-structure-and-function-of-a-member-of-the-l-amino-acid-transporter-lat-family\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Characterisation of the structure and function of a member of the L-Amino acid Transporter (LAT) family - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"Scientists at the Institute for Research in Biomedicine (IRB Barcelona)\u00a0in the Barcelona Science Park and the\u00a0CIBER of Rare Diseases (CIBERER)\u00a0\u2013 in collaboration with\u00a0the\u00a0Institute of Molecular Biology of Barcelona (IBMB-CSIC) at PCB,\u00a0and the Barcelona Supercomputing Center-Centro Nacional de Supercomputaci\u00f3n (BSC-CNS) \u2013\u00a0have now characterised the structure of a member of the\u00a0LAT family.\u00a0Mutations in L-amino acid transporters (LATs) can lead to a wide range of conditions, such as autism, hearing loss and aminoacidurias. 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