{"id":110712,"date":"2026-05-11T09:39:16","date_gmt":"2026-05-11T07:39:16","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/ibec-leads-the-beat-project-of-the-duchenne-parent-project-spain-association-to-stop-the-heart-damage-of-the-dystrophy\/"},"modified":"2026-05-11T15:45:56","modified_gmt":"2026-05-11T13:45:56","slug":"ibec-leads-the-beat-project-of-the-duchenne-parent-project-spain-association-to-stop-the-heart-damage-of-the-dystrophy","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/ibec-leads-the-beat-project-of-the-duchenne-parent-project-spain-association-to-stop-the-heart-damage-of-the-dystrophy\/","title":{"rendered":"IBEC leads the BEAT project of the Duchenne Parent Project Spain association to stop the heart damage of the dystrophy"},"content":{"rendered":"

Duchenne Parent Project Spain has invested \u20ac247,000 in the BEAT project, which will be carried out by the Institute of Bioengineering of Catalonia (IBEC<\/a>), based at the University of Barcelona Science Park (PCB-UB), with the aim of reducing progressive heart damage, one of the main challenges in Duchenne and Becker muscular dystrophies, since cardiomyopathy is the main cause of mortality in patients with DMD.<\/strong><\/p>\n

In this project, which has received an investment of \u20ac247,000 from DPPE, a \u2018heart-on-a-chip\u2019 platform will be developed. “This breakthrough will save vital time by reducing the number of animals required, enabling us to reproduce human heart tissue affected by the disease in a laboratory setting, monitor fibrosis (scar tissue) in real time, and test drug candidates,” explains Dr Marisol Montolio<\/strong>, Director of the Research Department at Duchenne Parent Project Spain.<\/p>\n

The lack of dystrophin \u2014 a protein that is absent or defective in these diseases \u2014 affects more than just skeletal muscle. It also compromises the heart muscle, promoting the development of fibrosis \u2014 a process whereby healthy tissue is replaced by scar tissue \u2014 which progressively weakens heart function. This leads to cell death and replacement by fibrotic tissue.<\/p>\n

The project will be led from the Institute for Bioengineering of Catalonia (IBEC) by Dr Juan Manuel Fern\u00e1ndez<\/strong>, a senior researcher in the Biosensors for Bioengineering group at IBEC and principal investigator of BEAT. The project will also involve collaboration with the Duchenne Parent Project Spain Patient Registry, the University of Ja\u00e9n, SJD Barcelona Children’s Hospital, and Newcastle University.<\/p>\n

“We will study cardiac pathology in mice and patients to build a 3D cardiac model that mimics the human disease. The heart-on-a-chip platform includes sensors that track damage and fibrosis in real time, helping us to identify and test promising treatments. This platform could also be used to study other heart diseases, accelerating drug discovery,’ explains Dr Fern\u00e1ndez.<\/strong><\/p>\n

Research driven by families<\/strong><\/h3>\n

For the Duchenne Parent Project in Spain, BEAT is a commitment to research that focuses on the real needs of patients and their families. One of the main concerns in the progression of the disease is cardiac involvement, which is why developing tools to better understand it and speed up the evaluation of treatments is a priority. \u201cBEAT is the pulse of our fight. It means heartbeat, but it also means to defeat. And that\u2019s exactly what we\u2019re going to do with the cardiomyopathy associated with Duchenne and Becker muscular dystrophies,\u201d says Silvia \u00c1vila<\/strong>, president of Duchenne Parent Project Spain.<\/p>\n

The project also involves families through an advisory committee to ensure that research remains aligned with the priorities of the Duchenne and Becker community. Through this initiative, Duchenne Parent Project Spain is strengthening its commitment to biomedical innovation and improving access to new therapeutic solutions, with the ultimate goal of enhancing the quality of life for those affected by Duchenne and Becker muscular dystrophies. Furthermore, to increase the funds allocated to this research, they have launched a crowdfunding campaign via the iHelp<\/a> platform.<\/p>\n

Duchenne muscular dystrophy (DMD) is a genetic, degenerative and incurable condition affecting around 1,100 people in Spain. Worldwide, it affects approximately 1 in every 5,000 children, with around 20,000 new cases diagnosed each year. It is characterised by the absence of dystrophin, a protein essential for muscle stability and function. This deficiency triggers a continuous cycle of damage and inflammation that accelerates muscle deterioration. Progression of the disease leads to a gradual loss of mobility, necessitating life support and round-the-clock home care, typically provided by family members from an early age.<\/p>\n

\u00bb Link to the news: <\/strong>IBEC website [+]<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Duchenne Parent Project Spain has invested \u20ac247,000 in the BEAT project, which will be carried out by the Institute of Bioengineering of Catalonia (IBEC), based at the University of Barcelona…<\/p>\n","protected":false},"author":14,"featured_media":110706,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[36],"tags":[],"class_list":["post-110712","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science"],"acf":[],"yoast_head":"\nIBEC leads the BEAT project of the Duchenne Parent Project Spain association to stop the heart damage of the dystrophy - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"description\" content=\"Duchenne Parent Project Spain has invested \u20ac247,000 in the BEAT project with the aim of reducing progressive heart damage.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/en\/ibec-leads-the-beat-project-of-the-duchenne-parent-project-spain-association-to-stop-the-heart-damage-of-the-dystrophy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IBEC leads the BEAT project of the Duchenne Parent Project Spain association to stop the heart damage of the dystrophy - 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