{"id":108616,"date":"2026-01-26T17:09:06","date_gmt":"2026-01-26T16:09:06","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/the-cnag-participates-in-a-study-that-identifies-the-first-case-of-spontaneous-genetic-correction-in-a-severe-immunodeficiency-linked-to-the-epstein-barr-virus\/"},"modified":"2026-01-26T17:09:06","modified_gmt":"2026-01-26T16:09:06","slug":"the-cnag-participates-in-a-study-that-identifies-the-first-case-of-spontaneous-genetic-correction-in-a-severe-immunodeficiency-linked-to-the-epstein-barr-virus","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/the-cnag-participates-in-a-study-that-identifies-the-first-case-of-spontaneous-genetic-correction-in-a-severe-immunodeficiency-linked-to-the-epstein-barr-virus\/","title":{"rendered":"The CNAG participates in a study that identifies the first case of spontaneous genetic correction in a severe immunodeficiency linked to the Epstein-Barr virus"},"content":{"rendered":"<p><strong>Researchers from the National Center for Genomic Analysis (<a href=\"https:\/\/www.pcb.ub.edu\/en\/empresa\/centre-nacional-danalisi-genomica-cnag\/\" target=\"_blank\" rel=\"noopener\">CNAG<\/a>), located at the Barcelona Science Park, have participated in a study led by the Infection and Immunity in Pediatric Patients group at VHIR, in collaboration with Hospital Sant Joan de D\u00e9u, Hospital de la Santa Creu i Sant Pau, and the Blood and Tissue Bank, which for the first time identifies a case of spontaneous correction of a genetic mutation in a patient with CD137 deficiency, a rare immunodeficiency that causes vulnerability to Epstein\u2013Barr virus (EBV) infection.<\/strong><\/p>\n<p>Congenital errors of immunity are disorders caused by genetic mutations that affect the functioning of the immune system. CD137 deficiency is one of these conditions, first described in 2019 and caused by a mutation in the TNFRSF9 gene. In these patients, CD8 T lymphocytes, a type of immune cell, are unable to mount an adequate response to Epstein\u2013Barr virus infection. This infection is very common in the general population and usually does not cause serious consequences, but in patients with this deficiency, it can persist for years and may even lead to certain types of lymphoma.<\/p>\n<h3><strong>A unique case of spontaneous improvement after a transplant<\/strong><\/h3>\n<p>The patient described in the study first presented with severe clinical manifestations of Epstein\u2013Barr virus (EBV) infection in 2012, at the age of 13, including the development of lymphoma. At that time, the genetic cause of her condition was still unknown, and she was therefore referred to Hospital de Sant Pau to undergo a bone marrow transplant from her brother, who was compatible and apparently healthy. The transplant enabled most T cells in her blood to originate from her brother; however, the patient continued to present high levels of the virus for years without clinical improvement. In 2019, her inclusion in a research project led by the Translational Immunology Group using high-throughput sequencing techniques enabled the genetic diagnosis of her condition: CD137 deficiency. It was also discovered that her brother carried the same mutation, despite being clinically asymptomatic, which explained why the patient had not improved after the transplant.<\/p>\n<p>A few years after the transplant, and unexpectedly, the patient experienced spontaneous clinical improvement and viral control without substantial changes in treatment. When the VHIR team, together with CNAG, analysed her immune cells in the blood using innovative single-cell sequencing techniques, they discovered that two CD8 T-cell lines derived from her brother had naturally corrected the original mutation once inside the patient\u2019s body (post-transplant).<\/p>\n<p>&#8220;This approach allowed us to determine that the cells with the corrected mutation originated from the donor, not the patient, and to observe that some of these cells were proliferating preferentially. This indicated that these cells had acquired a functional advantage within the immune system and that the phenomenon was not random,&#8221; says <strong>Dr Anna Esteve<\/strong>, author of the study and <a href=\"https:\/\/www.cnag.eu\/teams\/bioinformatics-unit\/functional-genomics-team\" target=\"_blank\" rel=\"noopener\">Leader of the Functional Genomics Team at CNAG<\/a>.<\/p>\n<p>This phenomenon is known as somatic reversion. In total, up to 20% of T cells in the blood showed this genetic reversion. \u201cAt some point after the transplant, these somatic mutations emerged and corrected the original genetic defects. This partially restored the immune response against the virus and improved the patient\u2019s clinical condition,\u201d explains <strong>Dr Laura Batlle Mas\u00f3<\/strong>, postdoctoral researcher in the Translational Immunology Group at VHIR. \u201cThis phenomenon had previously been described in other inborn errors of immunity, but this is the first time it has been detected in this particular disorder and, moreover, after a transplant,\u201d she adds.<\/p>\n<p>Over the years, the number of corrected cells has decreased, although they remain detectable in the patient\u2019s body. This decrease has coincided with an increase in viral load, making her medium-term clinical prognosis uncertain.<\/p>\n<p>This discovery is highly relevant from a scientific standpoint, as it provides proof of concept for the viability of future gene therapies. \u201cThe somatic reversion observed in this patient indicates that even a small proportion of corrected cells can improve the immune response to EBV, resulting in significant clinical benefit. This finding opens the door to the development of gene therapy for this disease. Since current gene therapies do not correct all target cells, demonstrating that partial restoration of immune function can translate into meaningful clinical benefit is essential,\u201d explains <strong>Dr Roger Colobran<\/strong>, head of the Translational Immunology Group at VHIR.<\/p>\n<p><strong>\u00bb Article of reference:<\/strong> Batlle-Mas\u00f3, Laura, et al. \u2018Somatic Reversion in CD137 Deficiency Correlating with Epstein-Barr Virus Control and Clinical Improvement\u2019. Npj Genomic Medicine, vol. 10, no. 1, Nov. 2025, p. 78. <a href=\"https:\/\/doi.org\/10.1038\/s41525-025-00535-y\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1038\/s41525-025-00535-y<\/a>.<\/p>\n<p><strong>\u00bb Access to the news: <\/strong><a href=\"https:\/\/www.cnag.eu\/news\/new-study-identifies-first-case-spontaneous-genetic-correction-severe-immunodeficiency-linked\">CNAG website [+]<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from the National Center for Genomic Analysis (CNAG), located at the Barcelona Science Park, have participated in a study led by the Infection and Immunity in Pediatric Patients group&#8230;<\/p>\n","protected":false},"author":14,"featured_media":108612,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[36],"tags":[235],"class_list":["post-108616","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science","tag-cnag-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The CNAG participates in a study that identifies the first case of spontaneous genetic correction in a severe immunodeficiency linked to the Epstein-Barr virus - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"description\" content=\"The study for the first time identifies a case of spontaneous correction of a genetic mutation in a patient with CD137 deficiency.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The CNAG participates in a study that identifies the first case of spontaneous genetic correction in a severe immunodeficiency linked to the Epstein-Barr virus - Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"og:description\" content=\"The study for the first time identifies a case of spontaneous correction of a genetic mutation in a patient with CD137 deficiency.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/\" \/>\n<meta property=\"og:site_name\" content=\"Parc Cient\u00edfic de Barcelona\" \/>\n<meta property=\"article:published_time\" content=\"2026-01-26T16:09:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2026\/01\/1769433694915-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"900\" \/>\n\t<meta property=\"og:image:height\" content=\"331\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Paula Ca\u00f1al\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Paula Ca\u00f1al\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\\\/\"},\"author\":{\"name\":\"Paula Ca\u00f1al\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/dece7d71551633ff3423502f3e384c6a\"},\"headline\":\"The CNAG participates in a study that identifies the first case of spontaneous genetic correction in a severe immunodeficiency linked to the Epstein-Barr virus\",\"datePublished\":\"2026-01-26T16:09:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\\\/\"},\"wordCount\":775,\"image\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/1769433694915-1.jpg\",\"keywords\":[\"CNAG\"],\"articleSection\":[\"SCIENCE\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\\\/\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\\\/\",\"name\":\"The CNAG participates in a study that identifies the first case of spontaneous genetic correction in a severe immunodeficiency linked to the Epstein-Barr virus - Parc Cient\u00edfic de Barcelona\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/1769433694915-1.jpg\",\"datePublished\":\"2026-01-26T16:09:06+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/dece7d71551633ff3423502f3e384c6a\"},\"description\":\"The study for the first time identifies a case of spontaneous correction of a genetic mutation in a patient with CD137 deficiency.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.pcb.ub.edu\\\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/1769433694915-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.pcb.ub.edu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/1769433694915-1.jpg\",\"width\":900,\"height\":331},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The CNAG participates in a study that identifies the first case of spontaneous genetic correction in a severe immunodeficiency linked to the Epstein-Barr virus\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#website\",\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/\",\"name\":\"Parc Cient\u00edfic de Barcelona\",\"description\":\"Universitat de Barcelona\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.pcb.ub.edu\\\/es\\\/#\\\/schema\\\/person\\\/dece7d71551633ff3423502f3e384c6a\",\"name\":\"Paula Ca\u00f1al\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b994665ec600f20526048e5d98eab6b8aa5e116b6fe2101daebcb986872bd355?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b994665ec600f20526048e5d98eab6b8aa5e116b6fe2101daebcb986872bd355?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b994665ec600f20526048e5d98eab6b8aa5e116b6fe2101daebcb986872bd355?s=96&d=mm&r=g\",\"caption\":\"Paula Ca\u00f1al\"},\"url\":\"https:\\\/\\\/www.pcb.ub.edu\\\/en\\\/author\\\/paula\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The CNAG participates in a study that identifies the first case of spontaneous genetic correction in a severe immunodeficiency linked to the Epstein-Barr virus - Parc Cient\u00edfic de Barcelona","description":"The study for the first time identifies a case of spontaneous correction of a genetic mutation in a patient with CD137 deficiency.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/","og_locale":"en_US","og_type":"article","og_title":"The CNAG participates in a study that identifies the first case of spontaneous genetic correction in a severe immunodeficiency linked to the Epstein-Barr virus - Parc Cient\u00edfic de Barcelona","og_description":"The study for the first time identifies a case of spontaneous correction of a genetic mutation in a patient with CD137 deficiency.","og_url":"https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/","og_site_name":"Parc Cient\u00edfic de Barcelona","article_published_time":"2026-01-26T16:09:06+00:00","og_image":[{"width":900,"height":331,"url":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2026\/01\/1769433694915-1.jpg","type":"image\/jpeg"}],"author":"Paula Ca\u00f1al","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Paula Ca\u00f1al","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/#article","isPartOf":{"@id":"https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/"},"author":{"name":"Paula Ca\u00f1al","@id":"https:\/\/www.pcb.ub.edu\/es\/#\/schema\/person\/dece7d71551633ff3423502f3e384c6a"},"headline":"The CNAG participates in a study that identifies the first case of spontaneous genetic correction in a severe immunodeficiency linked to the Epstein-Barr virus","datePublished":"2026-01-26T16:09:06+00:00","mainEntityOfPage":{"@id":"https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/"},"wordCount":775,"image":{"@id":"https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/#primaryimage"},"thumbnailUrl":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2026\/01\/1769433694915-1.jpg","keywords":["CNAG"],"articleSection":["SCIENCE"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/","url":"https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/","name":"The CNAG participates in a study that identifies the first case of spontaneous genetic correction in a severe immunodeficiency linked to the Epstein-Barr virus - Parc Cient\u00edfic de Barcelona","isPartOf":{"@id":"https:\/\/www.pcb.ub.edu\/es\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/#primaryimage"},"image":{"@id":"https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/#primaryimage"},"thumbnailUrl":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2026\/01\/1769433694915-1.jpg","datePublished":"2026-01-26T16:09:06+00:00","author":{"@id":"https:\/\/www.pcb.ub.edu\/es\/#\/schema\/person\/dece7d71551633ff3423502f3e384c6a"},"description":"The study for the first time identifies a case of spontaneous correction of a genetic mutation in a patient with CD137 deficiency.","breadcrumb":{"@id":"https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/#primaryimage","url":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2026\/01\/1769433694915-1.jpg","contentUrl":"https:\/\/www.pcb.ub.edu\/wp-content\/uploads\/2026\/01\/1769433694915-1.jpg","width":900,"height":331},{"@type":"BreadcrumbList","@id":"https:\/\/www.pcb.ub.edu\/el-cnag-participa-en-un-estudi-que-identifica-el-primer-cas-de-correccio-genetica-espontania-en-una-immunodeficiencia-greu-vinculada-al-virus-depstein-barr\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.pcb.ub.edu\/en\/"},{"@type":"ListItem","position":2,"name":"The CNAG participates in a study that identifies the first case of spontaneous genetic correction in a severe immunodeficiency linked to the Epstein-Barr virus"}]},{"@type":"WebSite","@id":"https:\/\/www.pcb.ub.edu\/es\/#website","url":"https:\/\/www.pcb.ub.edu\/es\/","name":"Parc Cient\u00edfic de Barcelona","description":"Universitat de Barcelona","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.pcb.ub.edu\/es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.pcb.ub.edu\/es\/#\/schema\/person\/dece7d71551633ff3423502f3e384c6a","name":"Paula Ca\u00f1al","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/b994665ec600f20526048e5d98eab6b8aa5e116b6fe2101daebcb986872bd355?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/b994665ec600f20526048e5d98eab6b8aa5e116b6fe2101daebcb986872bd355?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/b994665ec600f20526048e5d98eab6b8aa5e116b6fe2101daebcb986872bd355?s=96&d=mm&r=g","caption":"Paula Ca\u00f1al"},"url":"https:\/\/www.pcb.ub.edu\/en\/author\/paula\/"}]}},"_links":{"self":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/posts\/108616","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/comments?post=108616"}],"version-history":[{"count":0,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/posts\/108616\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/media\/108612"}],"wp:attachment":[{"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/media?parent=108616"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/categories?post=108616"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pcb.ub.edu\/en\/wp-json\/wp\/v2\/tags?post=108616"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}