{"id":106579,"date":"2025-10-07T09:50:26","date_gmt":"2025-10-07T07:50:26","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/scientists-from-ibec-manage-to-reverse-alzheimers-in-mice-using-nanoparticles\/"},"modified":"2025-10-08T09:44:05","modified_gmt":"2025-10-08T07:44:05","slug":"scientists-from-ibec-manage-to-reverse-alzheimers-in-mice-using-nanoparticles","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/scientists-from-ibec-manage-to-reverse-alzheimers-in-mice-using-nanoparticles\/","title":{"rendered":"Scientists from IBEC manage to reverse Alzheimer’s in mice using nanoparticles"},"content":{"rendered":"

An international team co-led by the Institute for Bioengineering of Catalonia (IBEC<\/a>), based at the Barcelona Science Park, and the West China Hospital of Sichuan University (WCHSU) has succeeded in reversing the progression of Alzheimer\u2019s disease in mice with just three injections of nanoparticles. The innovative approach to treating this condition focuses on restoring the normal function of the vascular system, rather than targeting neurons or other brain cells, as has commonly been done until now. This achievement, published in the journal Signal Transduction and Targeted Therapy<\/em>, represents a promising step toward an effective treatment for Alzheimer\u2019s disease.<\/strong><\/p>\n

Unlike traditional nanomedicine, which relies on nanoparticles as carriers of therapeutic molecules, IBEC researchers have designed \u201csupramolecular drugs\u201d \u2014 nanoparticles that are bioactive on their own. Instead of directly targeting neurons, the therapy restores the proper function of the blood-brain barrier (BBB), the vascular \u201cgatekeeper\u201d that regulates the brain\u2019s environment. By repairing this critical interface, the researchers were able to reverse Alzheimer\u2019s pathology in animal models.<\/p>\n

The brain is the most expensive organ of the body, consuming 20% of the energy in adults and up to 60% in children. This energy arrives through a vast blood supply, assured by a unique and dense vascular system, where each neuron is nourished by one capillary. Our brain contains approximately one billion capillaries, highlighting the vital role of brain vasculature in maintaining health and combating disease. These findings highlight the crucial role of vascular health, especially in diseases like dementia and Alzheimer\u2019s, where a compromised vascular system is closely linked.<\/p>\n

The BBB is a cellular and physiological barrier that separates the brain from the blood flow to protect it from external dangers such as pathogens or toxins. The team demonstrated that targeting a specific mechanism enables undesirable \u201cwaste proteins\u201d produced in the brain to pass through this barrier and be eliminated in the blood flow. In Alzheimer\u2019s disease, the main \u201cwaste\u201d protein is amyloid-\u03b2 (A\u03b2), whose accumulation impairs the normal functioning of the neurons.<\/p>\n

Researchers used mouse models that are genetically programmed to produce larger amounts of A\u03b2 protein and develop a significant cognitive decline mimicking Alzheimer\u2019s pathology. They administered only 3 doses of the supramolecular drugs and afterwards regularly monitored the evolution of the disease. “Only 1h after the injection we observed a reduction of 50-60% in A\u03b2 amount inside the brain” explains Junyang Chen<\/strong>, first co-author of the study, researcher at the West China Hospital of Sichuan University and PhD student at the University College London (UCL).<\/p>\n

The most striking data were the therapeutic effects. Researchers conducted various experiments to analyse the behaviour of the animals and measure their memory decline over several months, covering all stages of the disease. In one of the experiments, they treated a 12-month-old mouse (equivalent to a 60-year-old human) with the nanoparticles and analysed its behaviour after 6 months. The result was impressive: the animal, aged 18 months (comparable to a 90-year-old human), had recovered the behaviour of a healthy mouse.<\/p>\n

“The long-term effect comes from restoring the brain\u2019s vasculature. We think it works like a cascade: when toxic species such as amyloid-beta (A\u03b2) accumulate, disease progresses. But once the vasculature is able to function again, it starts clearing A\u03b2 and other harmful molecules, allowing the whole system to recover its balance. What\u2019s remarkable is that our nanoparticles act as a drug and seem to activate a feedback mechanism that brings this clearance pathway back to normal levels”, explains Giuseppe Battaglia<\/strong>, principal investigator of the Molecular Bionics group<\/a> and leader of the study.<\/p>\n

\"Light-sheet

Light-sheet fluorescence microscopy images of a mouse brain 12 hours after being treated (right) or not (left) with nanoparticles.<\/p><\/div>\n

Nanoparticles to treat Alzheimer\u2019s<\/strong><\/h3>\n

In this study, the researchers introduce nanoparticles that act as supramolecular drugs, therapeutic agents in their own right rather than carriers of medication. Designed with a bottom-up<\/em> molecular engineering approach, these nanoparticles combine precise size control with a defined number of surface ligands, creating a multivalent platform able to interact with cellular receptors in a highly specific way. By engaging receptor trafficking at the cell membrane, they open up a unique and novel way to modulate receptor function. This precision not only enables the effective clearance of amyloid-\u03b2 from the brain but also restores balance to the vascular system that maintains healthy brain function.<\/p>\n

This innovative therapeutic paradigm offers a promising pathway for developing effective clinical interventions, addressing vascular contributions to Alzheimer\u2019s disease, and ultimately enhancing patient outcomes. \u201cOur study demonstrated remarkable efficacy in achieving rapid A\u03b2 clearance, restoring healthy function in the blood\u2013brain barrier and leading to a striking reversal of Alzheimer\u2019s pathology.\u201d, concludes Lorena Ruiz P\u00e9rez<\/strong>, researcher at the Molecular Bionics group from the Institute for Bioengineering of Catalonia (IBEC) and Serra Hunter Assistant Professor in the Faculty of Physics at the University of Barcelona (UB).<\/p>\n

The study was a collaboration among the Institute for Bioengineering of Catalunya (IBEC), West China Hospital of Sichuan University, West China Xiamen Hospital of Sichuan University, University College London, the Xiamen Key Laboratory of Psychoradiology and Neuromodulation, University of Barcelona,Chinese Academy of Medical Sciences and the Catalan Institution for Research and Advanced Studies (ICREA).<\/p>\n

\u00bb Article of reference: <\/strong>Junyang Chen, Pan Xiang, Aroa Duro-Castano, Huawei Cai, Bin Guo, Xiqin Liu, Yifan Yu, Su Lui, Kui Luo, Bowen Ke, Lorena Ruiz P\u00e9rez, Xiawei Wei, Qiyong Gong, Xiaohe Tian, Giuseppe Battaglia. Multivalent modulation of endothelial LRP1 induces fast neurovascular amyloid-\u03b2 clearance and cognitive function improvement in Alzheimer\u2019s disease models. Signal Transduction and Targeted Therapy (2025).\u00a0doi: 10.1038\/s41392-025-02426-1<\/a><\/p>\n

\u00bb Link to the news: <\/strong>IBEC website [+]<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

An international team co-led by the Institute for Bioengineering of Catalonia (IBEC), based at the Barcelona Science Park, and the West China Hospital of Sichuan University (WCHSU) has succeeded in…<\/p>\n","protected":false},"author":14,"featured_media":106571,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[36],"tags":[231],"class_list":["post-106579","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science","tag-ibec-en"],"acf":[],"yoast_head":"\nScientists from IBEC manage to reverse Alzheimer's in mice using nanoparticles - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"description\" content=\"The approach to treating this disease focuses on restoring the normal function of the vascular system, rather than acting on the neurons.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/cientifics-de-libec-aconsegueixen-revertir-lalzheimer-en-ratolins-amb-lus-de-nanoparticules\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists from IBEC manage to reverse Alzheimer's in mice using nanoparticles - 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