{"id":103575,"date":"2025-04-17T09:37:30","date_gmt":"2025-04-17T07:37:30","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/nuage-therapeutics-ona-therapeutics-and-splicebio-are-leading-the-wave-of-biotech-innovation-in-barcelona\/"},"modified":"2025-10-13T14:57:36","modified_gmt":"2025-10-13T12:57:36","slug":"nuage-therapeutics-ona-therapeutics-and-splicebio-are-leading-the-wave-of-biotech-innovation-in-barcelona","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/nuage-therapeutics-ona-therapeutics-and-splicebio-are-leading-the-wave-of-biotech-innovation-in-barcelona\/","title":{"rendered":"Nuage Therapeutics, Ona Therapeutics, and SpliceBio are leading the wave of biotech innovation in Barcelona"},"content":{"rendered":"

The life sciences sector is experiencing a boom, and Barcelona is strengthening its position as a hub for biotech innovation with global reach. The Catalan capital\u2019s focus on specialization in health is supported by a robust ecosystem made up of universities, hospitals, research centers, and increasingly active investment that fosters the creation of spinoffs and startups. In this context, the biotech companies Nuage Therapeutics<\/a>, Ona Therapeutics<\/a>, and SpliceBio<\/a>, based at the Barcelona Science Park, have been spotted in a recent Nature<\/em> article as key representatives of a new generation of companies leading the sector\u2019s growth in the city.<\/strong><\/p>\n

According to the latest BioRegion Report 2024, prepared by Biocat<\/a>, the health sector is already the third-largest source of wealth in Catalonia, representing 7.6% of the region\u2019s GDP, with a business volume close to \u20ac45 billion last year. This growth is supported by a vibrant ecosystem, made up of 112 spinoffs and 470 active startups. Among them, Nuage Therapeutics<\/strong>, Ona Therapeutics<\/strong>, and SpliceBio<\/strong> stand out, featured in a recent Nature<\/em> article in a special section focused on scientific advances and key innovation trends. These three companies are emerging as major biotech promises, with research that could mark a turning point in the treatment of diseases that have so far been difficult to address.<\/p>\n

Nuage Therapeutics<\/strong> is focusing its oncology research on targeting a type of proteins that evade most currently available treatments. Intrinsically disordered proteins (IDPs) lack a fixed structure, are flexible and dynamic, which makes it difficult for traditional small molecules to bind to them\u2014posing a challenge for classical drug design strategies. \u201cWe have developed a technology that captures these proteins in vitro in a more ordered secondary conformation,\u201d CEO Stuart Hughes<\/strong> told Nature<\/em>. \u201cThis allows us to find drugs that bind to them in a way conventional drug discovery has not been able to.\u201d<\/p>\n

Currently, the startup is working on applying its proprietary technology to develop a new line of therapeutic agents aimed at oncogenic transcription factors. \u201cNuage Therapeutics has a highly differentiated set of technologies that allow us to capture \u2018disordered\u2019 proteins in a form suitable for small-molecule screening,\u201d says Hughes<\/strong>, who believes their technology \u201crepresents a revolutionary advance in drug discovery and precision medicine, especially in cases where the targets were previously considered undruggable.\u201d<\/p>\n

Another major challenge in oncology remains advanced cancer. Metastasis is responsible for the majority of cancer-related deaths\u2014a stage where the disease spreads and evolves to become resistant. Ona Therapeutics<\/strong> is aiming to fight cancer by creating therapies capable of counteracting the mechanisms that allow its spread and survival. Its antibody-drug conjugates (ADCs) combine targeted drugs with antibodies to act directly on tumor cells. Co-founder and CEO Valerie Vanhooren<\/strong> states that \u201cOna Therapeutics’ tailor-made ADCs have the potential to define new treatment paradigms and patient populations.\u201d<\/p>\n

The company\u2019s research focuses on detecting molecular changes that occur when cancer adapts to conventional therapies, using real patient samples. In the Nature<\/em> article, Haijun Sun<\/strong>, CSO of Ona Therapeutics, notes that \u201cby analyzing rare samples from patients with advanced-stage cancer, we\u2019ve been able to identify completely new drug targets that no one else is working on.\u201d Their lead drug candidate, ONA-255, is expected to enter clinical trials by the end of 2025 for the treatment of solid tumors such as breast and gastric cancers.<\/p>\n

In recent years, gene therapy has become a promising field for treating rare diseases, presenting a major opportunity for those capable of delivering innovative solutions. Developing effective treatments for these conditions\u2014many still incurable\u2014requires creativity, expertise, and new ways of thinking about science. The biotech company SpliceBio<\/strong> is betting on gene therapy to treat hereditary diseases caused by mutations in large genes.<\/p>\n

The company has developed a pioneering protein splicing technology based on a family of proprietary artificial proteins called inteins. This innovation has already been applied to its lead candidate, SB-007\u2014a gene therapy using two AAV vectors to treat Stargardt disease, an inherited retinal disorder caused by mutations in the ABCA4 gene. \u201cOur technology allows us to split the gene into two transgenes, which are delivered using our dual AAV vector,\u201d explains Miquel Vila-Perell\u00f3<\/strong>, co-founder and CEO of SpliceBio, in Nature<\/em>. \u201cOnce inside the cell, the DNA of each transgene is transcribed into messenger RNA and translated into protein. Then, our modified inteins assemble the complete protein needed to treat the disease.\u201d<\/p>\n

With examples like these three companies, Barcelona is establishing itself as a strategic hotspot in life sciences and is attracting increasing interest from the global pharmaceutical industry. Within Spain, Catalonia leads research activity, being the autonomous community with the highest number of clinical trials. Internationally, Spain ranks as the European country with the most registered clinical trials\u2014a position only surpassed by powerhouses like the United States, China, and Japan.<\/p>\n

\u00bb More information: <\/strong>Nature Portfolio. (2025, abril). Why biotech is booming in Barcelona. Nature.\u00a0https:\/\/www.nature.com\/articles\/d42473-025-00025-w<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The life sciences sector is experiencing a boom, and Barcelona is strengthening its position as a hub for biotech innovation with global reach. 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