{"id":102353,"date":"2025-02-25T17:12:16","date_gmt":"2025-02-25T16:12:16","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/irb-barcelona-researchers-discover-how-the-same-mutations-can-cause-different-leukaemias\/"},"modified":"2025-03-05T16:39:07","modified_gmt":"2025-03-05T15:39:07","slug":"irb-barcelona-researchers-discover-how-the-same-mutations-can-cause-different-leukaemias","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/irb-barcelona-researchers-discover-how-the-same-mutations-can-cause-different-leukaemias\/","title":{"rendered":"IRB Barcelona researchers discover how the same mutations can cause different leukaemias"},"content":{"rendered":"

A study by IRB Barcelona<\/a>, \u200b\u200bbased at the Barcelona Science Park, funded by the Fundaci\u00f3n CRIS contra el c\u00e1ncer<\/a> and led by ICREA researcher Dr. Alejo Rodr\u00edguez-Fraticelli, shows that the \u201cprevious state\u201d of blood stem cells has a decisive influence on the type of leukaemia that develops. The research, published in the journal Cell Stem Cell, describes the new STRACK technique that allows the step-by-step evolution of each cell to be followed before and after acquiring oncogenic mutations.<\/strong><\/p>\n

Myeloid leukaemias are among the most aggressive blood cancers and have low survival rates. Today, leukaemia patients undergo genetic analysis to identify mutations and select the most appropriate treatment. However, even among patients with the same mutation, disease progression and response to therapy can vary significantly.<\/p>\n

IRB Barcelona investigation has now revealed these differences can be explained by the fact that not all blood stem cells respond in the same way when they acquire a mutation, and the previous \u201cstate\u201d of the cell influences the development of cancer. In this regard, the researchers have identified two cell types\u2014one \u201cstronger\u201d and the other more \u201csensitive\u201d to inflammatory stimuli. This previous feature affects how the disease develops after acquisition of oncogenic mutations.<\/p>\n

\u201cBy gaining the mutations, both cell states can give rise to leukaemia, but with distinct biological properties that respond differently to treatment,\u201d explains Dr. Rodr\u00edguez-Fraticelli. <\/strong>The findings represent a step forward in understanding the vast diversity of these types of cancers and highlight the importance of analysing the cellular “state” prior to mutation.<\/p>\n

STRACK: high-precision tracking<\/strong><\/h3>\n

To perform this study, the researchers developed the STRACK technique (Simultaneous Tracking of Recombinase Activation and Clonal Kinetics). STRACK uses genetic bar codes to track each cell and monitor its behaviour before and after acquisition of the mutation.<\/p>\n

\u201cThis approach has allowed us for the first time to link the initial state of each cell with later cancerous features,\u201d say Indranil Singh<\/strong> and Dr. Daniel Fern\u00e1ndez P\u00e9rez<\/strong>, first authors of the study. Furthermore, the use of mouse models has made it possible to study the process in a fully physiological environment, and with controlled genetic features, which reinforces the significance of the findings.<\/p>\n

Towards more personalised therapies<\/strong><\/h3>\n

The conclusions drawn by this study suggest that, for leukaemia, identifying the genetic mutation alone is not enough to determine the most appropriate treatment. The \u201cprevious state\u201d of the cells, which can include their response to repeated inflammation or epigenetic changes, is crucial when predicting the tumour type and its response to treatment.<\/p>\n

These findings could apply to other types of cancer as cells in distinct tissues also accumulate \u201cmemories\u201d of inflammation or other damage, which would affect their behaviour. Understanding these factors, as well as the mutation, would facilitate the development of even more personalised treatments and preventive strategies focused on the avoidance of habits that predispose to the development of the most aggressive forms of the disease.<\/p>\n

This study was conducted entirely in the Quantitative Stem Cell Dynamics lab<\/a> at IRB Barcelona by the researchers Indranil Singh, Daniel Fernandez Perez, Pedro S\u00e1nchez S\u00e1nchez and Alejo E. Rodriguez-Fraticelli. The project received essential funding from Fundaci\u00f3n CRIS contra el c\u00e1ncer<\/strong>, through its programme \u201cCRIS Excelencia 2020\u201d, and from the European Research Council, through an ERC Starting Grant.<\/p>\n

\u00bb Reference article: <\/strong>Pre-existing stem cell heterogeneity dictates clonal responses to acquisition of leukemic driver mutations. Indranil Singh, Daniel Fernandez-Perez, Pedro S\u00e1nchez S\u00e1nchez, Alejo E. Rodriguez-Fraticelli. Cell Stem Cell (2025). doi:\u00a0https:\/\/doi.org\/10.1016\/j.stem.2025.01.012<\/a><\/p>\n

\u00bb Link to the news: <\/strong>IRB website [+]<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A study by IRB Barcelona, \u200b\u200bbased at the Barcelona Science Park, funded by the Fundaci\u00f3n CRIS contra el c\u00e1ncer and led by ICREA researcher Dr. Alejo Rodr\u00edguez-Fraticelli, shows that the…<\/p>\n","protected":false},"author":1,"featured_media":102349,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[36],"tags":[260],"class_list":["post-102353","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science","tag-irb-en"],"acf":[],"yoast_head":"\nIRB Barcelona researchers discover how the same mutations can cause different leukaemias - Parc Cient\u00edfic de Barcelona<\/title>\n<meta name=\"description\" content=\"These differences can be explained by the fact that not all blood stem cells respond in the same way to a mutation\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pcb.ub.edu\/investigadors-de-lirb-barcelona-descobreixen-com-les-mateixes-mutacions-poden-causar-leucemies-diferents\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IRB Barcelona researchers discover how the same mutations can cause different leukaemias - 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