{"id":101376,"date":"2025-01-17T16:11:57","date_gmt":"2025-01-17T15:11:57","guid":{"rendered":"https:\/\/www.pcb.ub.edu\/new-mechanism-identified-that-shields-persister-tumour-cells-from-the-immune-system\/"},"modified":"2025-01-17T16:51:31","modified_gmt":"2025-01-17T15:51:31","slug":"new-mechanism-identified-that-shields-persister-tumour-cells-from-the-immune-system","status":"publish","type":"post","link":"https:\/\/www.pcb.ub.edu\/en\/new-mechanism-identified-that-shields-persister-tumour-cells-from-the-immune-system\/","title":{"rendered":"New mechanism identified that shields persister tumour cells from the immune system"},"content":{"rendered":"<p><strong>A team led by Dr. Manuel Serrano at <a href=\"https:\/\/www.pcb.ub.edu\/en\/empresa\/institut-de-recerca-biomedica-irb-barcelona\/\" target=\"_blank\" rel=\"noopener\">IRB Barcelona<\/a>, based in the Barcelona Science Park, \u00a0has identified inflammatory gene silencing as a distinctive feature of persister tumour cells, thereby paving the way for the development of new treatments. The study, published in the journal Cancer Research, marks a step forward in the fight against resistance to cancer treatment. By targeting persister cells, the likelihood of relapse could be reduced, thus improving patient prognosis.<\/strong><\/p>\n<p>Cancer therapies do not always succeed in eliminating tumour cells. Some of these cells enter a state of senescence\u2014a latent, non-dividing state that is generally irreversible. Others, however, enter a state known as &#8216;persister,&#8217; where dormancy is temporary and reversible. This state allows the cells to begin growing again after the treatment has ended, leading to cancer recurrence.<\/p>\n<p>A team led by\u00a0<strong>Dr. Manuel Serrano<\/strong>\u00a0at IRB Barcelona has discovered a key strategy through which these persister cells evade the immune response and resist cancer treatments. Specifically, the study reveals that persister cells block the genes responsible for inflammation through an epigenetic mechanism that acts as a &#8216;molecular lock,&#8217; preventing these genes from becoming activated and alerting the immune system.<\/p>\n<p>This lock stops the immune system from detecting and eliminating these cells, allowing them to resist treatment. This contrasts with senescent cells, which are highly inflammatory and use different mechanisms to evade the immune response.<\/p>\n<p>\u201cThis epigenetic silencing is a weakness of persister cells and could be leveraged to design new therapeutic approaches,\u201d says\u00a0<strong>Dr. Serrano<\/strong>, head of the study and currently working at Altos Labs (Cambridge, UK).<\/p>\n<h3><strong>A promising therapeutic approach<\/strong><\/h3>\n<p>In addition to identifying this mechanism, the study shows that inhibiting the epigenetic mechanism could unlock inflammatory genes and compromise the viability of persister cells, thus paving the way for the development of new therapies.<\/p>\n<p>\u201cThe goal is to be able to develop drugs that selectively target persister cells and strengthen the effect of conventional treatments&#8221;, explains <strong>Dr. Valentina Ramponi, <\/strong>\u00a0first-authored, and<strong>\u00a0<\/strong>now a postdoctoral researcher at the AIRC Institute of Molecular Oncology.<\/p>\n<p>This discovery marks a step forward in the fight against resistance to cancer treatment. By targeting persister cells, the likelihood of relapse could be reduced, thus improving patient prognosis.<\/p>\n<p>This study has been done in collaboration with the Rovira i Virgili University, the Queen Mary University of London, the CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), the AIRC Institute of Molecular Oncology, and Altos Labs\u2019 Cambridge Institute of Science.<\/p>\n<p>The study was funded by the European Research Council (ERC), the Spanish Association Against Cancer, the European Molecular Biology Organization (EMBO), and the Barcelona Institute of Science and Technology (BIST).<\/p>\n<p><strong>\u00bb Reference article: <\/strong>Valentina Ramponi<span class=\"al-author-delim\">,\u00a0<\/span>Laia Richart<span class=\"al-author-delim\">,\u00a0<\/span>Marta Kovatcheva<span class=\"al-author-delim\">,\u00a0<\/span>Camille Stephan-Otto Attolini<span class=\"al-author-delim\">,\u00a0<\/span>Jordi Capellades<span class=\"al-author-delim\">,\u00a0<\/span>Alice E. Lord<span class=\"al-author-delim\">,\u00a0<\/span>Oscar Yanes<span class=\"al-author-delim\">,\u00a0<\/span>Gabriella Ficz<span class=\"al-author-delim\">,\u00a0<\/span>Manuel Serrano; H4K20me3-Mediated Repression of Inflammatory Genes Is a Characteristic and Targetable Vulnerability of Persister Cancer Cells.\u00a0<em>Cancer Res<\/em>\u00a01 January 2025; 85 (1): 32\u201351. doi:\u00a0<a href=\"http:\/\/doi.org\/10.1158\/0008-5472.CAN-24-0529\" target=\"_blank\" rel=\"noopener\">10.1158\/0008-5472.CAN-24-0529<\/a><\/p>\n<p><strong>\u00bb Link to the news: <\/strong><a href=\"https:\/\/www.irbbarcelona.org\/en\/news\/scientific\/new-mechanism-identified-shields-persister-tumour-cells-immune-system\" target=\"_blank\" rel=\"noopener\">IRB Barcelona website [+]<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team led by Dr. Manuel Serrano at IRB Barcelona, based in the Barcelona Science Park, \u00a0has identified inflammatory gene silencing as a distinctive feature of persister tumour cells, thereby&#8230;<\/p>\n","protected":false},"author":14,"featured_media":101369,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[36],"tags":[],"class_list":["post-101376","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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