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The architecture of mitochondria: health and disease

By 2 de October de 2009November 18th, 2020No Comments
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The architecture of mitochondria: health and disease

Researchers at IRB Barcelona publish a review article in Physiological Reviews about the changes in the shape and movements of mitochondria, and the human diseases associated with defects in these processes. This review establishes a new interface between cell biology and pathology.

The authors –Marc Liesa, Manuel Palacín i Antonio Zorzano– anticipate that the pharmaceutical industry will show increased interest in the proteins that participate in mitochondrial dynamics if it is confirmed that they are directly involved in the development of complex diseases. The proteins that act in the outer membrane of mitochondria, such as MFN2 are particularly promising therapeutic targets.

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