Experimental Toxicology and Ecotoxicology

The Experimental Toxicology and Ecotoxicology (UTOX) Platform offers research and development services in the domain of toxicology, ADME and Microbiology for the pharmaceutical, veterinary, medical devices, personal hygiene, food, cosmetics, chemical and nanotechnology sectors.

The platform is a member of the Centro de Investigación en Toxicología (CERETOX), and it is GLP-certified in the healthcare domain to engage in all types of in vitro and in vivo regulatory studies.Contract

  • Research projects (CRO).
  • ADME service.
    • Bioanalytical method qualification.
    • Pharmacokinetic studies.
  • In vitro experimental toxicology services
    • Evaluation of toxic and genotoxic effects, efficacy, permeability and haemocompatibility.
    • Development of cell lines and tissues, ex vivo or reconstructed.
    • Quantification of active substances and biomarkers.
    • Mutagenicity and genotoxicity, cytotoxicity, neurotoxicity, mitochondrial toxicity, irritation and sensitisation, bioavailability, dermal permeability, cosmetic efficacy studies.In vivo
  • toxicology service.
    • Genotoxicity.
    • Acute or repeat-dose toxicity via multiple administration routes.
    • Development toxicology.
    • Palatability.
    • Irritation/tolerance.
    • Sensitisation.
    • Implanting of medical devices.
    • Field studies.
    • Clinical pathology and pathological service for haematological, biochemical, urine, coagulation test, specific biomarker, histotechnical analysis.
  • Ecotoxicology Service.
    • Evaluation of the risk or safety of products in environmental terms for water species (algae, crustaceans and fish), land species (nitrifying bacteria, worms and plants).
    • Field studies to evaluate environmental toxicity or genotoxicity in different organisms and biosystems.
  • Microbiology Department
    • Determination of the minimum inhibitory concentration (MIC) in specific resistant and non-resistant bacteria.
    • Challenge tests.
    • Inocula control.
    • Endotoxin determination.
    • Blood cultures.
  • Expert, safety and risk analysis reports.
  • Assessment and consultancy.

Other scientific services:

Animal facility
Institutional Animal Care and Use Committee (IACUC)