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Recycling within amyloid-beta fibrils might be a clue to the cause of Alzheimer’s disease

By 13 de April de 2011November 18th, 2020No Comments
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 13.04.2011

Recycling within amyloid-beta fibrils might be a clue to the cause of Alzheimer’s disease

A research study, published yesterday (Tuesday, 12 April 2011) in the Journal of the American Chemical Society (JACS), demonstrates that the aggregation of amyloid-beta (Aβ) proteins into amyloid fibrils characteristic of Alzheimer's disease (AD) is not irreversible, as previously thought. The Aβ protein molecules that comprise the fibrils are continuously detaching from and re-attaching to the fibrils, resulting in molecular recycling.


These findings suggest that recycling could be a source of small non-fibrillar Aβ aggregates, which are believed to be responsible for the neurodegeneration observed in AD. The authors of this study, experts in protein structure and aggregation at IRB Barcelona, located at the barcelona scientific Park– and other research centers, led by the ICREA researcher Nàtalia Carulla, believe that modulation of fibril recycling may lead to the development of new therapeutic approaches to treat this disease.