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27 October 2023 @ 12:00 - 13:30

Cell To Cell Communication In Glioblastoma Progression

Speaker: Sergio Casas Tintó, PhD – Instituto de Investigación de Enfermedades Raras (IIER-AGH) – Unidad de Enfermedades Humanas en Drosophila – Instituto de Salud Carlos III – Madrid.

Abstract:

Glioblastoma (GB) is the most aggressive, lethal and frequent primary brain tumor. It originates from glial cells and is characterized by rapid expansion through infiltration. We have studied how GB cells interact with the microenvironment and healthy surrounding tissues, mostly neurons. GB cells project tumor microtubes (TMs) that contact with neighboring neurons, and exchange signaling molecules related to Wingless/WNT, JNK, Insulin or Neuroligin-3 pathways. This cell to cell communication promotes GB expansion and synapse loss in the neurons. Moreover, healthy neurons form glutamatergic functional synapses with GB cells which facilitate GB expansion and premature death. Targeting signaling and synaptic components of GB progression may become a suitable strategy against glioblastoma. In a Drosophila GB model, we have determined the post-synaptic nature of GB cells with respect to neurons, and the contribution of post-synaptic genes expressed in GB cells to tumor progression. In addition, we document the presence of intratumoral synapses between GB cells, and the functional contribution of pre-synaptic genes to GB calcium dependent activity and expansion. Finally, we explore the relevance of synaptic genes in GB cells to the lifespan reduction caused by GB advance. Our results indicate that both presynaptic and postsynaptic proteins play a role in GB progression and lethality.

Details

Date:
27 October 2023
Time:
12:00 - 13:30
Event Category:
Website:
https://www.irbbarcelona.org/ca/events/cell-cell-communication-glioblastoma-progression

Organizer

IRB Barcelona – Institut de Recerca Biomedica
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Venue

Edifici Cluster I, Aula Fèlix Serratosa
C/ Baldiri Reixac 10-12
Barcelona, Barcelona 08028 Espanya
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Phone
934037171
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