Basement membranes (BMs) are polymers of matrix proteins underlying epithelia and surrounding organs in all animals. BMs and Collagen IV, their main component, are actually the key evolutionary innovations allowing the existence of tissues and the evolution of complex body plans in the Metazoa. In my laboratory, we are trying to understand the biology of tissues and BMs using the fruit fly Drosophila melanogaster as a model organism, mostly through genetics and cell biology approaches. During my talk, I will present our findings regarding the secretion of Collagen IV, the hierarchy of assembly of BM components and the developmental roles of BMs in mechanically shaping tissues and regulation of tissue growth. In addition, I will discuss recent data from my laboratory showing that Collagen IV can mediate intercellular adhesion through a novel form of matrix organization that we call CIVICs (Collagen IV Intercellular Concentrations).
Cell and Developmental Biology Programme Seminar
Fecha y hora de inicio: 19/07/2017, 15.00h
Fecha y hora de fin: 19/07/2017, 17.00h
Organizador: IRB - Institut de Rercerca Biomèdica
Sitio: Edifici Clúster Laboratoris, Aula Félix Serratosa
Host: Marco Milán, IRB Barcelona