< Tornar al llistat

Barcelona BioMed Seminar: Immunometabolism as a driver of senescence and aging


Mitochondrial dysfunction is a hallmark of aging. Our aim is to characterize how perturbations of mitochondrial function, specifically in cells of the immune system, affect organism homeostasis and lifespan. To explore this hypothesis, we are using a mouse model whose mitochondrial function is compromised by deletion of mitochondrial transcription factor Tfam, specifically in T lymphocytes. The absence of Tfam induces a severe decrease in mtDNA content resulting in severe mitochondrial dysfunction and impaired oxidative phosphorylation, thus forcing a metabolic switch towards glycolysis. Glycolytic T cells acquire proinflammatory features provoking a cytokine storm resembling inflammaging characterized by high serum levels of IL6, TNF, and IFN-. CD4Tfam-/- mice display reduced body weight, kyphosis, altered glucose homeostasis, sarcopenia, and cardiovascular alterations. On the whole, CD4Tfam-/- mice serve as an innovative genetic model for frailty and premature aging, reflecting the importance of tight immunometabolic control in preventing sterile inflammation and delaying aging and the onset of age-associated diseases.

Molecular Medicine Programme Seminar

Data i hora d'inici: 19/09/2018, 13.00h

Data i hora de fi: 19/09/2018, 14.30h

Organitzador: IRB - Institut de Recerca Biomèdica

Lloc: Edifici Clúster Laboratoris, Aula Félix Serratosa

Host: Manuel Serrano, PhD