Barcelona BioMed Seminar: CRISPR screens and data integration to prioritise new therapeutic targets in cancer
Descripció: Functional genomics approaches can overcome limitations that hamper oncology drug development such as lack of robust target identification and poor clinical efficacy. We performed genome-scale CRISPR-Cas9 screens in 324 human cancer cell lines from 30 cancer types and developed a data-driven framework to prioritise cancer therapeutic candidates. We integrated cell fitness effects with genomic biomarkers and target tractability for drug development to systematically prioritise new targets in defined tissues and genotypes. We verified one of our most promising dependencies, Werner syndrome ATP-dependent helicase, as a synthetic-lethal target in tumours from multiple cancer types with microsatellite instability. Our analysis provides a comprehensive resource of cancer dependencies, generates a framework to prioritise oncology targets, and nominates specific new targets. The principles described in this study can inform the initial stages of drug development by contributing a new, diverse and more effective portfolio of oncology targets.
Data i hora d'inici: 20/09/2019, 12.00h
Data i hora de fi: 20/09/2019, 14.00h
Organitzador: IRB - Institut de Recerca Biomèdica
Lloc: Edifici Clúster Laboratoris, Aula Félix Serratosa
Host: Patrick Aloy, PhD - IRB Barcelona