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2006
-
E. Giralt. Current efforts to understand and modulate peptide
(and protein) self-assembly. Peptide Science, 43,
150 (2006).
-
I.
Belda, S. Madurga, T. Tarragó, X. Llora, E. Giralt. Evolutionary
computation and multimodal search: A good combination to tackle
molecular diversity in the field of peptide design. Mol
Divers. 2006 Dec 13.
-
O.P. Gulin, F. Rabanal, E. Giralt. Efficient preparation of
proline N-carboxyanhydride using polymer-supported bases. Org
Lett. 2006 Nov 9; 8(23):5385-8.
-
J.
Vila, J. Sanchez-Cespedes, J.M. Sierra, M. Piqueras, E. Nicolas,
J. Freixas, E. Giralt. Antibacterial evaluation of a collection
of norfloxacin and ciprofloxacin derivatives against multiresistant
bacteria. International Journal of Antimicrobial Agents
(2006), 28(1), 19-24
-
Gracia, Carolina; Isidro-Llobet, Albert; Cruz, Luis J.; Acosta,
Gerardo A.; Alvarez, Mercedes; Cuevas, Carmen; Giralt, Ernest;
Albericio, Fernando. Journal of Organic Chemistry (2006),
71(19), 7196-7204
-
E. Costa, S. Canudas, I. Garcia-Bassets, S. Perez, I. Fernandez,
E. Giralt, F. Azorin, M. Ll. Espinas. Drosophila dSAP18 is a
nuclear protein that associates with chromosomes and the nuclear
matrix, and interacts with pinin, a protein factor involved
in RNA splicing. Chromosome Research (2006), 14(5),
515-526
-
J.
Villén, R. Rodríguez-Mías, J. I. Núñez,
E. Giralt, F. Sobrino & D. Andreu. Rational dissection of
Binding Surfaces for Mimicking of Discontinuous Antigenic Sites.
Chem. & Biol., 13(8), 815-823
(2006).
-
S.
Pujals, J. Fernandez-Carneado, M.J. Kogan, J. Martinez, F. Cavelier,
E. GiraltS. Replacement of a Proline with Silaproline Causes
a 20-Fold Increase in the Cellular Uptake of a Pro-Rich Peptide.
J. Am. Chem. Soc. (2006), 128(26),
8479-8483
-
M.
Gairí, P. Saiz, S. Madurga, X. Roig, J. Erchegyi, S.C.
Koerber, J.C. Reubi, J.E. Rivier & E. Giralt. Conformational
analysis of a potent SSTR3-selective somatostatin analogue by
NMR in water solution. J.Pep.Sci., 12,
82-91 (2006).
-
M.J.
Kogan, N.G. Bastus, R. Amigo, D. Grillo-Bosch, E. Araya, A.
Turiel, A. Labarta, E. Giralt & V.F. Puntes. Nanoparticle-Mediated
Local and Remote Manipulation of Protein Aggregation. Nano
Letters, 6, 110-115 (2006)
-
S.
Marti; J. Sanchez-Cespedes, E. Oliveira, D. Bellido, E. Giralt,
J. Vila. Proteomic analysis of a fraction enriched in cell envelope
proteins of Acinetobacter baumannii. Proteomics (2006),
6 Suppl 1 S82-7
-
L.J.
Cruz, C. Cuevas, L.M. Canedo, E. Giralt & F. Albericio.
Total solid-phase synthesis of marine cyclodepsipeptide IB-01212.
J.Org.Chem. 71(9), 3339-3344
-
L.J.
Cruz, M. Martinez, J. Perez, M. Trujillo, R. Rodriguez-Mias,
E. Oliveira, E. Giralt, F. Albericio, L.M. Canedo. IB-01212,
a new cytotoxic cyclodepsipeptide isolated from the marine fungus
Clonostachys sp. J.Org.Chem. (2006), 71(9), 3335-3338
-
S.Frutos,
T.Tarragó & E. Giralt. A fast and robust 19F-NMR
based method for finding new HIV-1 protease inhibitors. Bioorg.Med.Chem.Lett.
(2006), 16(10), 2677-2681
-
M.Lamiri
, K.Bougrin , B.Daou , E.Nicolas & E.Giralt and Mohamed
Soufiaoui. Microwave-assisted solvent-free synthesis of 5-alkylidene
and 5-arylidenehydantoins. Synthetic Communications
(2006), 36(11), 1575-1584
-
T.Tarragó, S.Frutos, R.A. Rodriguez-Mias & E.Giralt.
Identification of traditional Chinese medicinal plants with
prolyl oligopeptidase inhibitory activity using 19F-NMR. ChemBioChem
(2006), 7(5), 827-833
-
S.Pujals, J.Fernández-Carneado, C.López-Iglesias,
M.J. Bogan & E.Giralt. Mechanistic aspects of CPP-mediated
intracellular drug delivery: relevance of CPP self-assembly.
BBA-Biomembranes (2006), 1758(3), 264-279
-
M.Martinell,
X.Salvatella, J.Fernández-Carneado, S.Gordo, M.Feliz,
M.Menéndez, E.Giralt. Synthetic ligands able to interact
with the P53. Tetramerization Domain. Towards understanding
a protein surface recognition event. ChemBioChem (2006),
7(7), 1105-1113
2005
-
Nicolas, Ernesto; Ferrer, Cristina; Taboada, Lorena; Giralt,
Ernest. Coupe du Roi Bisection of Proteins. Spontaneous Tetramerization
of Two Peptides That Span the Sequence of the Rabbit Uteroglobin
Monomer. J. Am. Chem. Soc., 127(50),
17719-17733 (2005).
-
N. Carulla, G.L. Caddy, D.R. Hall, J. Zurdo, M.Gairí,
M. Feliz, E. Giralt, C.V. Robinson & C.M. Dobson. Molecular
recycling within amyloid fibrils. Nature, 436,
554-558 (2005).
- J.
Fernández-Carneado, M. Van Gool, V. Martos, S. Castel,
P. Prados, J. de Mendoza and E. Giralt. A new class of highly
efficient, non-peptidic oligoguanidinium vectors that selectively
internalize into mitochondria. J. Am. Chem. Soc, 127,
869-874 (2005).
- J.
Farrera-Sinfreu, E. Giralt, S. Castel, F. Albericio and M. Royo.
Cell penetrating cis-g-amino-L-proline derived peptides.
J. Am. Chem. Soc., 127, 9459-9468 (2005).
- L.
Crespo, G. Sanclimens, M. Pons, E. Giralt, M. Royo, F. Albericio.
Peptide and amide bond containing dendrimers. Chem. Rev.,
105, 1663-1681 (2005).
- Förg,
U. Ziegler, J. Fernández-Carneado, E. Giralt, R. Rennert,
A.G. Beck-Sickinger and H.P. Merckle. Decoding the entry of
two novel cell-penetrating peptides in HeLa cells: lipid raft-mediated
endocytosis and endosomal escape. Biochemistry, 44,
72-81 (2005).
-
M. Teixidó, F. Albericio and E. Giralt. Solid-phase characterisation
of N-methyl-rich peptides. J. Pep. Res., 65,
153-166 (2005).
-
E. Escobar-Díaz, E.M. López-Martín, M.
Hernández del Cerro, A. Puig-Kroger, V. Soto-Cerrato,
B. Montaner, E. Giralt, J.A. García-Marco, R. Pérez-Tomás
and A. García-Pardo. AT514, a cyclic depsipeptide from
Serrratia marcescens, induces apoptosis of. B-chronic lymphocytic
leukemia cells: interference with the Akt/NF-kB survival pathway.
Leukemia, 19, 572-579 (2005).
- F.
Albericio, E. Giralt, J. Spengler and J.-C. Jiménez.
Abbreviated nomenclatura for cyclic and branched homo- and hetero-detic
peptides. J. Peptide Res., 65, 550–55
(2005).
-
J. Fernández-Carneado, M.J. Kogan, N. Van Mau, S. Pujals,
C. López-Iglesias, F. Heitz and E. Giralt. Fatty acyl
moieties: improving Pro-rich peptide uptake inside HeLa cells.
J. Peptide Res., 65, 580–590
(2005)
- T.
Tarragó, E. Sabidó, M.J. Kogan, E. de Oliveira
and E. Giralt. Primary structure, recombinant expression and
homology modelling of human brain prolyl oligopeptidase, an
important therapeutic target in the treatment of neuropsychiatric
diseases. J. Pep. Sci., 11, 283-287
(2005).
- B.
Montaner, W. Castillo-Ávila, M. Martinell, R. Oëllinger,
J. Aymami, E. Giralt and R. Pérez-Tomás. DNA Interaction
and Dual Topoisomerase I and II Inhibition. Properties of the
Anti-Tumor Drug Prodigiosin. Toxicological Sci., 85,
870–879 (2005).
-
C. Bonet, I. Fernández, X. Aran, J. Bernués, E.
Giralt and F. Azorín. The GAGA Protein of Drosophila
is Phosphorylated by CK2. J. Mol. Biol., 351,
562–572 (2005).
-
G. Sanclimens, L. Crespo, E. Giralt, F.Albericio and M. Royo
Preparation of de Novo Globular Proteins Based on Proline Dendrimers.
J. Org. Chem. 70, 6274-6281 (2005).
-
S. Madurga, I. Belda, X. Llorà, and E. Giralt. Design
of enhanced agonists through the use of a new virtual screening
method: Application to peptides that bind class I major histocompatibility
complex (MHC) molecules. Protein Sci., 14,
2069 – 2079 (2005).
-
Soto-Cerrato, B. Montaner, M. Martinell, M. Vilaseca, E. Giralt,
R. Pérez-Tomás. Cell cycle arrest and proapoptotic
effects of the anticancer cyclodepsipeptide serratamolide (AT514)
are independent of p53 status in breast cancer cells. Biochem.
Pharmacol., 71, 32 – 41 (2005).
- M.
Teixidó, I. Belda, E. Zurita, X. Llorà, M. Fabre,
S. Vilaró, F. Albericio, E. Giralt. Evolutionary combinatorial
chemistry, a novel tool for SAR studies on peptide transport
across the blood–brain barrier. Part 2. Design, synthesis
and evaluation of a first generation of peptides. J. Pep.
Sci. 11, 789–804 (2005)
-
I. Belda, S. Madurga, X. Llorà, M. Martinell, T. Tarragó,
M.G. Piqueras, E. Nicolás & E. Giralt. ENPDA: an
evolutionary structure-based de novo peptide design algorithm.
Journal of Computer-Aided Molecular Design, 3,
1-17 (2005).
-
J. Vila, J. Sánchez-Céspedes & E. Giralt.
Old and new strategies for the discovery of antibacterial agents.
Curr.Med.Chem – Anti-infective Agents, 4,
337-353 (2005).
-
P.Lloyd-Williams, E. Giralt. Stereogenic centers and axes: a
comparison of the chiral topologies available to Cabcd and abC=C=Ccd.
J. Chem. Edu., 82(7), 1031-1033 (2005).
-
G. Sanclimens, H. Shen, E. Giralt, F. Albericio, M.W. Saltzman
& M. Royo. Synthesis and screening of a small library of
proline-based biodendrimers for use as delivery agents.
Biopolymers 80, 800-814 (2005).
-
V. Soto-Cerrato, B. Montaner, M. Martinell, M. Vilaseca, E.
Giralt & R. Perez-Tomas. Cell cycle arrest and proapoptotic
effects of the anticancer cyclodepsipeptide serratamolide (AT514)
are independent of p53 status in breast cancer cells. Biochem.
Pharmacology, 71, 32-41 (2005).
-
J.M. Sierra, L. Martínez-Martínez, F. Vázquez,
E. Giralt and J. Vila. Relationship between mutations in the
gyrA gene and quinolone resistance in clinical isolates of Corynebacterium
striatum and corynebacterium amycolatum. Antimicrob. Agents
Chemother., 49, 1714-1719 (2005).
- Montaner,
Beatriz; Castillo-Avila, Wilmar; Martinell, Marc; Oellinger,
Rupert; Aymami, Joan; Giralt, Ernest; Perez-Tomas, Ricardo.
DNA Interaction and Dual Topoisomerase I and II Inhibition Properties
of the Anti-Tumor Drug Prodigiosin. Toxicological Sciences,
85(2), 870-879 (2005).
-
E. Escobar-Díaz, E.M. López-Martín, M.
Hernández del Cerro, A. Puig-Kroger, V. Soto-Cerrato,
B. Montaner, E. Giralt, J.A. García-Marco, R. Pérez-Tomás
and A. García-Pardo. AT514, a cyclic depsipeptide from
Serrratia marcescens, induces apoptosis of. B-chronic lymphocytic
leukemia cells: interference with the Akt/NF-kB survival pathway.
Leukemia, 19, 572-579 (2005).
- M.
Arimon, I. Díez-Pérez, M.J. Kogan, N. Durany,
E. Giralt, F. Sanz and X. Fernàndez-Busquets. Fine structure
study of Ab1-42fibrillogenesis with atomic force microscopy.
FASEB, 19, 1344-1346 (2005).
- I.
Belda, X. Llorà and E. Giralt. Evolutionary algorithms
and de novo peptide design. Soft. Comput., 10,
295-304 (2005).
2004
-
J.
Farrera-Sinfreu, L. Zaccaro, D. Vidal, X. Salvatella, E. Giralt,
M. Pons, F. Albericio and M. Royo. J. Am. Chem. Soc.,
126 (19), 6048-6057 (2004).
- J.
Fernández-Carneado, M. J. Kogan, S. Castel and E. Giralt.
Amphipathic Pro-rich peptides derived from the N-terminal domain
of g-zein as potential peptide carriers. Angew. Chem. Int.
Ed., 43, 1811-1814 (2004).
- X.
Salvatella, M. Martinell, M. Gairí, M. G. Mateu, M. Feliz,
A.D. Hamilton, J. de Mendoza and E. Giralt. A tetraguanidinium
ligand binds to the surface of the tetramerization domain of protein
P53. Angew. Chem. Int. Ed., 43, 196-198
(2004).
- H.
Mira, M. Vilar, V. Esteve, M. Martinell, M.J. Kogan, E. Giralt,
D. Salom, I. Mingarro, L. Penarrubia and E. Perez-Paya. BMC
Structural Biology (2004)
-
I.
Belda, X. Llorà, M. Martinell and E. Giralt. Computer-aided
peptide evolution for virtual drug design. Lectures Notes
in Computer Science, 3012, 321-332, Part
1 (2004)
-
M.
Prieto, E. Zurita, E. Rosa, L. Muñoz, P. Lloyd-Williams
and E. Giralt. Arylboronic acids and arylpinacolboronate esters
in Suzuki coupling reactions involving indoles. Partner role
swapping and heterocycle protection. J. Org. Chem.,
69, 6812-6820 (2004).
-
S.
Izquierdo, M.J. Kogan, T. Parella, A.G. Moglioni, V. Branchadell,
E. Giralt and R.M. Ortuño. 14-Helical folding in a cyclobutane-containing
b-tetrapeptide. J. Org. Chem., 69,
5093-5099 (2004)
-
M.
Cruz, J.M. Tusell, D. Grillo-Bosch, F. Albericio, J. Serratosa,
F. Rabanal and E. Giralt. Inhibition of b-amyloid toxicity by
short peptides containing N-methylaminoacids. J. Pep. Res.,
63, 324-328 (2004)
-
M.
Gutiérrez-Rodríguez, M. Martín-Martínez,
M.T. García-López, R. Herranz, F.Cuevas, C.Polanco,
I. Rodríguez-Campos, I. Manzanares, F. Càrdenas,
M. Feliz, P. Lloyd Williams and E. Giralt. Synthesis, conformational
analysis, and cytotoxicity of conformationally constrained aplidine
and tamandarin A analogues incorporating a spirolactam b-turn
mimetic. J. Med. Chem. 47, 5700-5712
(2004)
-
G.
Sanclimens, L. Crespo, E. Giralt, M. Royo and F.Albericio. Solid-phase
synthesisi of second generation polyproline dendrimers. Biopolymers,
76, 283-293
-
J.
Fernández-Carneado and E.Giralt. An efficient method
for the solid-phase synthesis of fluorescently labelled peptides.
Tetrahedron Lett, 45, 6079-6081
-
M.J.
Kogan, O. López, M. Cocera, C. López-Iglesias,
A. de la Mata and E. Giralt. Exploring the interaction of the
surfactant N-terminal domain of gamma-zein with soybean phosphatidylcholine
liposomes. Biopolymers, 73, 258-268
(2004).
-
J. Fernández-Carneado, M.J. Kogan, S. Pujals and E. Giralt.
Amphipatic Peptides and Drug Delivery. Biopolymers,
76 (2), 196-203 (2004).
-
K. Bisetty, J. Gómez-Catalán, C. Alemán,
E. Giralt, H. G. Kruger and J.J. Pérez. Computational
Study of the Conformational Preferences of the (R)-8-Amino-pentacyclo(5.4.0.02,6.03,10.05,9)
undecano-8-carboxylic Acid Monopeptide. J. Peptide Sci.,
10, 274-284 (2004).
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